皮肌炎作为宫颈癌继发的副肿瘤综合征：一种罕见的临床关联。

文献信息

中文摘要

皮肌炎（DM）是一种罕见的特发性炎性肌病，以对称性近端肌无力和特征性皮肤表现为特点。它常与潜在恶性肿瘤相关，因此识别副肿瘤特征至关重要。我们报告一例61岁绝经后女性，表现为进行性近端肌无力、吞咽困难和面部、颈部及四肢特征性皮损6个月。通过血清学、肌电图和肌肉活检的全面评估，确诊为DM。进一步检查发现潜在宫颈肿块，活检确诊为宫颈非角化性鳞状细胞癌（IIB期）。患者接受全身性皮质类固醇治疗后部分改善，并在同步放化疗后肌肉力量和吞咽困难均显著临床恢复。本病例强调了对新发DM患者评估隐匿性恶性肿瘤的重要性，并突出了DM与宫颈癌之间罕见但值得注意的关联。

英文摘要

Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy characterized by symmetric proximal muscle weakness and distinctive cutaneous manifestations. It is frequently associated with underlying malignancies, making recognition of paraneoplastic features crucial. We report the case of a 61-year-old postmenopausal woman who presented with progressive proximal muscle weakness, dysphagia, and characteristic skin lesions over the face, neck, and extremities for 6 months. Thorough evaluation with serology, electromyography, and muscle biopsy confirmed the diagnosis of DM. Further investigation revealed an underlying cervical mass, and biopsy established the diagnosis of non-keratinizing squamous cell carcinoma of the cervix (Stage IIB). The patient showed partial improvement with systemic corticosteroids and demonstrated significant clinical recovery in both muscle strength and dysphagia following concurrent chemoradiotherapy. This case highlights the importance of evaluating patients with new-onset DM for occult malignancy and underscores the rare but noteworthy association between DM and cervical carcinoma.