一只山羊的嗅神经母细胞瘤

文献信息

中文摘要

背景： 鼻腔肿瘤在山羊中不常见，最常报道的是淋巴瘤、地方性鼻腔肿瘤和息肉。鼻腔神经外胚层肿瘤很少被描述，而嗅神经母细胞瘤（ONB）是一种罕见的神经上皮性肿瘤，起源于筛板，在该物种中文献记载很少。本文报告了一只确诊为ONB的8岁山羊的临床表现和尸检发现。该山羊因慢性呼吸音异常病史后出现呼吸窘迫就诊，X线检查发现右侧鼻腔浸润性肿块。由于预后不良，实施了安乐死。尸检显示，鼻腔双侧被一个圆形、奶油灰色、柔软的肿块占据，大小为1×3 cm，并延伸至鼻咽部。组织学上，根据其浸润性生长以及典型的Homer Wright和Flexner-Wistersteiner样菊形团模式，诊断为恶性神经上皮性肿瘤。使用由细胞角蛋白AE1/AE3、细胞角蛋白8、β III微管蛋白、波形蛋白、COX-2、E-钙黏蛋白、嗜铬粒蛋白A和突触素组成的抗体组合进行了免疫组化表征。免疫表型证实了ONB的诊断，肿瘤细胞仅对细胞角蛋白AE1/AE3和β-III微管蛋白呈阳性。据作者所知，这是山羊中ONB的首次描述。

英文摘要

Nasal tumours are uncommon in goats, with lymphoma, enzootic intranasal tumours and polyps being the most commonly reported. Nasal neuroectodermal tumours are rarely described and olfactory neuroblastoma (ONB), an infrequent neuroepithelial neoplasm originating from the cribriform plate, is poorly documented in this species. Herein we report the clinical presentation and necropsy findings of an 8-year-old goat with a confirmed diagnosis of ONB. The goat was presented in respiratory distress following a history of chronic respiratory noise and an intranasal, right-side infiltrative mass was detected on radiographs. Due to the poor prognosis, euthanasia was performed. Post-mortem examination revealed that the nasal cavity was bilaterally occupied by a round, creamy-grey, soft mass measuring 1 × 3 cm and extending to the nasopharynx. Histologically, a malignant neuroepithelial neoplasm was diagnosed based on its infiltrative growth and the characteristic pattern of Homer Wright and Flexner-Wistersteiner-like rosettes. Immunohistochemical characterization was performed using an antibody panel composed of cytokeratin AE1/AE3, cytokeratin 8, beta III tubulin, vimentin, COX-2, E-cadherin, chromogranin A and synaptophysin. The immunoprofile confirmed the diagnosis of an ONB, with neoplastic cells being only positive for cytokeratin AE1/AE3 and beta-III tubulin. To the best of the authors' knowledge this is the first description of ONB in goats.