青少年大麻相关呼吸消化道症状：一例球部感、吞咽困难和唾液分泌过多的病例报告。

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中文摘要

背景： 青少年中大麻使用仍然普遍，产品效力和给药途径的不断演变引发对其对口咽和食管功能影响认识不足的担忧。方法：一名16岁男性在每日使用大麻2年后出现球部感、吞咽困难和唾液分泌过多。包括柔性喉镜检查和钡餐食管造影在内的广泛评估均无异常。经验性使用质子泵抑制剂、抗生素和抗过敏药物治疗效果甚微。结果：停止使用大麻后症状部分改善，并使用格隆溴铵后进一步改善，持续戒断后症状进一步缓解。结论：本病例强调了青少年慢性大麻使用与不明原因呼吸消化道症状（包括吞咽困难、球部感和唾液分泌过多）之间的时间关联。成人研究表明大麻素介导的食管运动改变，但青少年特异性数据有限。替代病因，包括嗜酸性食管炎，由于未进行内镜活检而未被排除，仍有可能。

英文摘要

Cannabis use remains common among adolescents, and evolving product potency and routes of administration raise concern for underrecognized effects on oropharyngeal and esophageal function. A 16-year-old male presented with globus sensation, dysphagia, and hypersalivation after 2 years of daily cannabis use. Extensive evaluation, including flexible laryngoscopy and barium esophagram, was unremarkable. Empiric treatment with proton pump inhibitors, antibiotics, and allergy medications offered minimal benefit. Symptoms partially improved after cannabis cessation and with glycopyrrolate, with further resolution following sustained abstinence. This case highlights a temporal association between chronic cannabis use and unexplained aerodigestive symptoms, including dysphagia, globus sensation, and hypersalivation in an adolescent. Adult studies suggest cannabinoid-mediated alterations in esophageal motility, but adolescent-specific data are limited. Alternative etiologies, including eosinophilic esophagitis, which was not excluded due to the absence of endoscopy with biopsies, remain possible.