非酒精性脂肪性肝病患者睡眠质量与阻塞性睡眠呼吸暂停的评估：一项横断面研究。
Evaluation of sleep quality and obstructive sleep apnea in non-alcoholic fatty liver disease: a cross-sectional study.
文献信息
| PMID | 42773422 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Sahar Ravanshad |
| 作者单位 | Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. |
| 期刊 | BMC gastroenterology |
| SCI 分区 | Q2 |
| IF | 3.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
背景： 睡眠对代谢稳态和整体健康至关重要。NAFLD（最近被重新分类为MASLD）是全球最常见的慢性肝病（患病率约25%），并与代谢合并症密切相关。越来越多的证据将不良睡眠状况（包括短睡眠时间、OSA和昼夜节律失调）与NAFLD的发生和进展联系起来。然而，来自伊朗和中东人群的数据仍然稀缺，且尚无研究在大型伊朗NAFLD队列中同时评估睡眠质量和OSA风险。本研究旨在使用PSQI和STOP-BANG问卷填补这一空白。
方法： 这项横断面研究利用了Mashhad医科大学PERSIAN组织队列研究（POCS）的登记数据。共纳入958例经腹部超声诊断的NAFLD患者。
结果： 在958名参与者中（69.6%为男性；平均年龄46.7±9.1岁），35.4%存在睡眠障碍（31.6%为轻度；3.8%为中度）。超过一半（53.4%）处于中等OSA风险。睡眠障碍与女性（p=0.022）、单身婚姻状况（p=0.019）、较高BMI（p=0.026）和高血压（p=0.007）显著相关。BMI与PSQI评分呈弱但显著相关（r=0.072，p=0.036）。肝脂肪变性分级与睡眠障碍无关（p=0.193），但与STOP-BANG评分呈正相关（r=0.232，p<0.001）。
结论： 睡眠障碍和OSA风险升高在NAFLD患者中常见，并且在未调整分析中与女性、BMI升高、高血压和单身婚姻状况相关。这些发现支持基于病例发现理由在该人群中考虑进行睡眠评估；识别或治疗这些状况是否能改善肝脏或代谢结局，无法从横断面研究中确定。
英文摘要
BACKGROUND: Sleep is essential for metabolic homeostasis and overall health. NAFLD, recently reclassified as MASLD, is the most prevalent chronic liver disease globally (~ 25% prevalence) and is strongly linked to metabolic comorbidities. Growing evidence associates adverse sleep conditions including short sleep duration, OSA, and circadian misalignment with NAFLD onset and progression. However, data from Iranian and Middle Eastern populations remain scarce, and no study has simultaneously evaluated sleep quality and OSA risk in a large Iranian NAFLD cohort. This study aimed to address this gap using the PSQI and STOP-BANG questionnaire.
METHODS: This cross-sectional study utilized registry data from the PERSIAN Organizational Cohort Study (POCS) at Mashhad University of Medical Sciences. A total of 958 NAFLD patients diagnosed by abdominal ultrasonography were included.
RESULTS: Among 958 participants (69.6% male; mean age 46.7 ± 9.1 years), 35.4% had sleep disturbance (31.6% mild; 3.8% moderate). Over half (53.4%) were at intermediate OSA risk. Sleep disturbance was significantly associated with female sex (p = 0.022), single marital status (p = 0.019), higher BMI (p = 0.026), and hypertension (p = 0.007). BMI correlated weakly but significantly with PSQI scores (r = 0.072, p = 0.036). Hepatic steatosis grade was not associated with sleep disturbance (p = 0.193) but correlated positively with STOP-BANG scores (r = 0.232, p < 0.001).
CONCLUSIONS: Sleep disturbance and elevated OSA risk are common among patients with NAFLD and were associated, in unadjusted analyses, with female sex, elevated BMI, hypertension and single marital status. These findings support consideration of sleep assessment in this population on case-finding grounds; whether identifying or treating these conditions improves hepatic or metabolic outcomes cannot be determined from a cross-sectional study.