年龄相关性听力损失中类淋巴系统、神经流体功能障碍与外周炎症的关联
Association of glymphatic system, neurofluidic dysfunction, and peripheral inflammation in age-related hearing loss.
文献信息
| PMID | 42772709 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Xudan Chen |
| 作者单位 | Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China. |
| 期刊 | NeuroImage |
| SCI 分区 | Q1 |
| IF | 6.6 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 年龄相关性听力损失（ARHL）与认知下降相关，但其机制仍不清楚。本研究检测了ARHL中四项与类淋巴和神经流体功能相关的互补MRI指标，并结合血浆炎症和神经退行相关生物标志物及认知评估。
方法： 66名ARHL参与者和139名匹配对照接受了认知测试（MoCA、MMSE、CFT-d）、基于MRI的类淋巴评估（DTI-ALPS、FW-WM、CPV、gBOLD-CSF），以及TNF-α、IL-1β、IL-6、NfL、p-tau181、GFAP和Aβ40的测量。进行了相关性和中介分析。
结果： ARHL参与者表现出更差的认知、更高的炎性细胞因子、增加的CPV和FW-WM以及降低的ALPS。较差的听力与较高的炎性细胞因子水平、较低的ALPS和较高的FW-WM相关。中介分析显示，较低的ALPS部分中介了PTA与认知下降之间的关联，TNF-α和IL-1β进一步参与其中。CPV和FW-WM随听力阈值增加而增加，而gBOLD-CSF耦合显示出非线性关联。
结论： ARHL与较差的认知表现、与类淋巴和神经流体功能相关的多模态MRI标志物改变以及循环炎性细胞因子升高相关。这些汇聚性发现确定了ARHL中认知障碍的潜在神经流体和炎症相关因素。
英文摘要
OBJECTIVE: Age-related hearing loss (ARHL) is linked to cognitive decline, but mechanisms remain unclear. This study examined four complementary MRI measures related to glymphatic and neurofluid function in ARHL, together with plasma inflammatory and neurodegeneration-related biomarkers and cognitive assessments.
METHODS: Sixty-six ARHL participants and 139 matched controls underwent cognitive testing (MoCA, MMSE, CFT-d), MRI-based glymphatic evaluation (DTI-ALPS, FW-WM, CPV, gBOLD-CSF), and measurement of TNF-α, IL-1β, IL-6, NfL, p-tau181, GFAP, and Aβ40. Correlation and mediation analyses were performed.
RESULTS: ARHL participants showed poorer cognition, higher inflammatory cytokines, increased CPV and FW-WM, and reduced ALPS. Worse hearing correlated with higher inflammatory cytokine levels, lower ALPS, and higher FW-WM. Mediation analysis revealed that lower ALPS partly mediated the association between PTA and cognitive decline, with TNF-α and IL-1β further contributing. CPV and FW-WM increased with hearing thresholds, while gBOLD-CSF coupling showed a nonlinear association.
CONCLUSION: ARHL was associated with poorer cognitive performance, altered multimodal MRI markers related to glymphatic and neurofluid function, and elevated circulating inflammatory cytokines. These convergent findings identify potential neurofluidic and inflammatory correlates of cognitive impairment in ARHL.