Article record

资源有限环境下前庭神经鞘瘤的临床特征、管理方式与手术结局：来自大马士革的多中心回顾性队列研究

Clinical Characteristics, Management Patterns, and Surgical Outcomes of Vestibular Schwannoma in a Resource-Limited Setting: A Multicenter Retrospective Cohort Study from Damascus.

临床研究耳科IF 2.1Q2

文献信息

PMID	42772630
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Samah Jalal Jabr 查看其他 7 位作者 Jalal Alkadry；Joudi Aldandashli；Dima Al-Karad；Louai Nahas；Samer Ayoubi；Ramez Baghdadi；Anas Alshawa
作者单位	Faculty of Medicine, Syrian Private University, Damascus, Syria. Electronic address: samahjaber888@gmail.com. 查看其他 7 条单位信息 Faculty of Medicine, Syrian Private University, Damascus, Syria. Electronic address: jalal_alkadry@spu.edu.sy.；Faculty of Medicine, Syrian Private University, Damascus, Syria. Electronic address: joudi_aldandashli@spu.edu.sy.；Faculty of Medicine, Syrian Private University, Damascus, Syria. Electronic address: demaalkrad@gmail.com.；Faculty of Medicine, Syrian Private University, Damascus, Syria. Electronic address: drlouei@gmail.com.；Department of Neurosurgery, Al-Abbassyeen Hospital, Damascus, Syria. Electronic address: drsamerayoubi@hotmail.com.；Department of Neurosurgery, Al-Abbassyeen Hospital, Damascus, Syria. Electronic address: Ramezbaghdade@hotmail.com.；Northwestern University. Electronic address: anas.alshawa@nm.org.
期刊	World neurosurgery
SCI 分区	Q2
IF	2.1
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

背景： 前庭神经鞘瘤是一种引起病残的良性第八脑神经肿瘤。我们描述了来自叙利亚大马士革手术队列的肿瘤特征和结局。
方法： 这项多中心回顾性队列纳入50例经组织病理学确诊的前庭神经鞘瘤患者，他们于2020年1月至2025年12月在四家医院接受手术。肿瘤按直径分为小型（≤25 mm）、中型（26-35 mm）或大型（>35 mm）。术前和术后结局采用McNemar检验进行比较；与肿瘤大小的关联采用卡方检验评估。
结果： 平均年龄为46 ± 13岁（范围19-72岁）；32例（64%）为女性。肿瘤位于右侧27例（54%），左侧23例（46%）；小型6例（12%），中型23例（46%），大型21例（42%），44例（88%）>25 mm。术前，听力损失发生于46例（92%），平衡障碍35例（70%），头痛29例（58%），耳鸣21例（42%），面部麻木/感觉异常19例（38%），面神经功能障碍11例（22%）。手术后，这些分别记录于32例（64%）、5例（10%）、6例（12%）、2例（4%）、5例（10%）和30例（60%）（所有p < 0.001）。未发现肿瘤大小与听力或面神经结局之间存在显著关联（p = 0.446-0.913）。
结论： 大多数患者就诊时为中大型肿瘤并伴有病残。手术后，若干症状的记录频率降低，而面神经功能障碍在术后记录频率更高。未证明肿瘤大小与听力或面神经结局之间存在显著关联。鉴于回顾性设计和转诊环境，应谨慎解读这些发现。

英文摘要

BACKGROUND: Vestibular schwannoma is a benign eighth cranial nerve tumor causing morbidity. We characterized tumor features and outcomes in a surgical cohort from Damascus, Syria.
METHODS: This multicenter retrospective cohort included 50 patients with histopathologically confirmed vestibular schwannoma who underwent surgery at four hospitals from January 2020 to December 2025. Tumors were classified by diameter as small (≤25 mm), medium (26-35 mm), or large (>35 mm). Preoperative and postoperative outcomes were compared using McNemar tests; associations with tumor size were assessed using chi-square tests.
RESULTS: Mean age was 46 ± 13 years (range, 19-72); 32 (64%) were female. Tumors were right-sided in 27 (54%) and left-sided in 23 (46%); 6 (12%) were small, 23 (46%) medium, and 21 (42%) large, 44 (88%) >25 mm. Preoperatively, hearing loss occurred in 46 (92%), balance disturbance in 35 (70%), headache in 29 (58%), tinnitus in 21 (42%), facial numbness/paresthesia in 19 (38%), and facial nerve dysfunction in 11 (22%). Following surgery, these were documented in 32 (64%), 5 (10%), 6 (12%), 2 (4%), 5 (10%), and 30 (60%), respectively (all p < 0.001). No significant associations were found between tumor size and hearing or facial nerve outcomes (p = 0.446-0.913).
CONCLUSIONS: Most patients presented with medium or large tumors and morbidity. Following surgery, several symptoms were less frequently documented, whereas facial nerve dysfunction was more frequently documented postoperatively. No significant association between tumor size and hearing or facial nerve outcomes was demonstrated. Findings should be interpreted considering the retrospective design and referral setting.