多组学视角下的慢性鼻窦炎伴鼻息肉：脂质组学、蛋白质组学和转录组学综述。

文献信息

中文摘要

本综述总结了慢性鼻窦炎伴鼻息肉（CRSwNP）多组学研究的最新进展，重点关注脂质组学、蛋白质组学和转录组学。CRSwNP是一种高度异质性疾病，以持续性炎症、上皮屏障功能障碍和组织重塑为特征，具有高复发率和多变的治疗反应。目前的研究多局限于单组学分析，很少实现系统的跨层整合。本综述整合了三个组学层面的证据，以构建连续的病理网络，识别稳定且可转化的生物标志物，并支持分层管理和精准治疗。

英文摘要

This review summarizes recent advances in multi-omics research on chronic rhinosinusitis with nasal polyps (CRSwNP), focusing on lipidomics, proteomics, and transcriptomics. CRSwNP is a highly heterogeneous disease characterized by persistent inflammation, epithelial barrier dysfunction, and tissue remodeling, with high recurrence and variable treatment responses. Current studies are mostly limited to single-omics analyses, and few achieve systematic cross-layer integration. This review integrates evidence from three omics layers to construct a continuous pathological network, identify stable and translatable biomarkers, and support stratified management and precision therapy.