全身免疫炎症指数在突发性感音神经性听力损失发生与预后中的价值：一项Meta分析
The Value of Systemic Immune-Inflammation Index in the Occurrence and Prognosis of Sudden Sensorineural Hearing Loss: A Meta-Analysis.
文献信息
| PMID | 42767670 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Feifei Sun |
| 作者单位 | Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital Southeast University (Jiangbei), Nanjing Dachang Hospital, Nanjing, Jiangsu, China. |
| 期刊 | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery |
| SCI 分区 | Q2 |
| IF | 2 |
| 研究类型 | 综述 Meta · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 突发性感音神经性听力损失（SSNHL）是常见的耳鼻咽喉科急症。本研究旨在评估全身免疫炎症指数（SII）与SSNHL发生及预后的关联。
设计： 系统评价与Meta分析。
场所： 包括PubMed、Embase、Cochrane Library、Web of Science、CNKI、万方、维普和中国生物医学文献数据库在内的数据库。
参与者： 来自11项研究的共1263名参与者，包括716例SSNHL患者和547名健康对照。
主要结局指标： SII水平的加权均数差（WMD）和95%置信区间（CI）。
结果： 本Meta分析纳入11项研究，涉及1263名参与者，其中716例为SSNHL患者，547名为健康对照。合并结果显示，SSNHL患者的SII显著高于健康对照（WMD=393.46，95% CI：222.02-564.91，p<0.001）。此外，听力恢复组的SII显著低于未恢复组（WMD=-208.36，95% CI：-412.27至-4.34，p=0.045）。
结论： SII升高与SSNHL的发生及较差的听力恢复相关。然而，仍需进一步开展对混杂因素进行充分调整的前瞻性研究，以明确其独立预后价值和临床实用性。
英文摘要
OBJECTIVES: Sudden sensorineural hearing loss (SSNHL) is a common otolaryngology emergency. This study aimed to evaluate the association of the systemic immune-inflammation index (SII) with the occurrence and prognosis of SSNHL.
DESIGN: Systematic review and meta-analysis.
SETTING: Databases including PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, VIP, and SinoMed.
PARTICIPANTS: A total of 1263 participants from 11 studies, comprising 716 SSNHL patients and 547 healthy controls.
MAIN OUTCOME MEASURES: Weighted mean difference (WMD) and 95% confidence interval (CI) for SII levels.
RESULTS: This meta-analysis included 11 studies involving 1263 participants, of whom 716 were SSNHL patients and 547 were healthy controls. The pooled results showed that SII was significantly higher in SSNHL patients than in healthy controls (WMD = 393.46, 95% CI: 222.02-564.91, p < 0.001). In addition, SII was significantly lower in the hearing recovery group than in the non-recovery group (WMD = -208.36, 95% CI: -412.27 to -4.34, p = 0.045).
CONCLUSION: Elevated SII is associated with SSNHL occurrence and poorer hearing recovery. However, further prospective studies with adequate adjustment for confounders are required to clarify its independent prognostic value and clinical utility.