眼科诊所中1岁以下接受视网膜母细胞瘤治疗的婴儿的麻醉：888例回顾性分析

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中文摘要

背景： 关于12个月以下婴儿在诊所环境中接受麻醉的安全性数据有限。视网膜母细胞瘤是最常见的儿童眼内恶性肿瘤，通常需要在诊所环境中进行门诊眼科手术时实施全身麻醉。
方法： 这是一项回顾性研究，纳入237名婴儿（<12个月）在MSKCC（2014-2024年）因视网膜母细胞瘤诊断和局限性眼内治疗而进行的888次诊所麻醉。主要结局是24小时内需要再入院的麻醉相关并发症发生率。次要结局包括麻醉持续时间、恢复时间、气道管理方式以及阿片类或非阿片类镇痛药的使用。
结果： 未发生麻醉相关再入院。麻醉持续时间中位数为43分钟（0-6个月）和36分钟（7-<12个月）；恢复时间中位数分别为36分钟和25分钟。喉罩气道在824例（93%）中使用。
结论： 在门诊诊所环境中，对于接受无需麻醉性镇痛药的局限性眼内治疗手术的视网膜母细胞瘤婴儿，全身麻醉可以是安全的。

英文摘要

BACKGROUND: Safety data for infants under 12 months undergoing anesthesia in clinic settings is limited. Retinoblastoma, the most common pediatric intraocular cancer, often requires general anesthesia for outpatient ophthalmology procedures in a clinic setting.
METHODS: This is a retrospective study of 888 anesthesia encounters in 237 infants (< 12 months) undergoing clinic visits at MSKCC (2014-2024) for the diagnosis and localized intraocular treatment of retinoblastoma. The primary outcome was the incidence of anesthesia-related complications requiring readmission within 24 h. Secondary outcomes included anesthesia duration, recovery time, airway management approach, and use of opioid or non-opioid analgesia.
RESULTS: No anesthesia-related readmissions occurred. Median anesthesia duration was 43 min (0-6 months) and 36 min (7-< 12 months); median recovery times were 36 and 25 min, respectively. Laryngeal mask airways were used in 824 (93%) cases.
CONCLUSIONS: General anesthesia in outpatient clinic settings can be safe for infants with retinoblastoma undergoing non-narcotic-requiring localized intraocular treatment procedures.