泡沫微片、传统泡腾片与速溶片之间功能差异的综述。

文献信息

中文摘要

泡沫微片（FMTs）是一种小尺寸泡腾片（ETs），保留了传统泡腾片通常具有的许多功能。然而，FMTs 并不仅仅是 ETs 的微型版本；它们代表一种创新剂型，可带来健康益处，并提供传统 ETs 无法提供的诸多优势。速溶片（FTs）可能与 FMTs 相似，本文也将其与 ETs 和 FMTs 进行比较讨论。本综述旨在探讨 FMTs、传统 ETs 和 FTs 之间的功能相似性与差异，以及这些差异背后的机制。例如，由于其更高的比表面积（SSA），FMTs 具有更高的活性成分载量和更快的活性成分释放速度，优于 FTs。FMTs 还可以将不相容的活性成分组合到单次剂量中，通过不同片剂的混合物提供协同健康益处。多种服用方式也是 FMTs 的一个关键且独特的属性，因为它们既可以溶于水中饮用，也可以直接放入口中服用。相比之下，ETs 只能在水完全崩解后服用，而 FTs 则直接放入口中服用。还值得注意的是，FTs 比 FMTs 和 ETs 崩解更快，而后者对吞咽困难者更容易。FTs 快速崩解的机制相当不同：将干片放入口中，在那里迅速崩解。这主要是由于基础 FT 配方中使用了超级崩解剂，而不是 ETs 和 FMPs 中使用的泡腾混合物。本文详细考察了 FMTs、ETs 和 FTs 的优势与局限性，提供了对这三种剂型的首个全面综述。

英文摘要

Foamed micro-tablets (FMTs) are small-sized effervescent tablets (ETs) that retain many functionalities typically associated with conventional ETs. However, FMTs are not merely miniature versions of ETs; they represent an innovative dosage form that delivers health benefits and offers numerous advantages that traditional ETs cannot provide. Fast-melt tablets (FTs), which may resemble FMTs, are also discussed in comparison with both ETs and FMTs. This review aims to explore the functional similarities and differences among FMTs, conventional ETs, and FTs, as well as the mechanisms underlying these variations. For example, FMTs have a higher active load and a quicker release of active ingredients than FTs due to their higher specific surface area (SSA). FMTs can also combine incompatible actives into a single dose, delivering synergistic health benefits from a mixture of different tablets. Multiple means of consumption are another key and distinct attribute of FMTs, as they can be consumed either by dissolving in water and drinking or by taking them directly to the mouth. In contrast, ETs can only be consumed after complete disintegration in water, whereas FTs are taken directly in the mouth. It is also noted that FTs disintegrate more quickly than FMTs and ETs, which are easier for people with swallowing difficulties. The mechanism for rapid disintegration of FTs is quite different: the dry tablet is placed in the mouth, where it disintegrates rapidly. This is primarily due to the use of superdisintegrants in the base FT formulation rather than the effervescent mix used in ETs and FMPs. This paper provides a detailed examination of the advantages and limitations of FMTs, ETs, and FTs, providing the first comprehensive review of these three dosage forms.