产前母亲应激与子代过敏性鼻炎风险：一项系统综述和荟萃分析
Prenatal maternal stress and the risk of allergic rhinitis in offspring: A systematic review and meta-analysis.
文献信息
| PMID | 42762557 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Zixin Liu |
| 作者单位 | Xiangtan Medicine & Health Vocational College, Xiangtan, Hunan, 411104, China. Electronic address: 675615978@qq.com. |
| 期刊 | International journal of pediatric otorhinolaryngology |
| SCI 分区 | Q2 |
| IF | 1.7 |
| 研究类型 | 综述 Meta · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 产前母亲应激影响胎儿免疫系统的发育，并可能增加儿童期过敏性鼻炎（AR）的风险。本荟萃分析对孕期母亲应激与子代随后发生AR之间的关系进行了系统性评估。
目的： 探讨产前母亲应激与子代AR风险之间的关系。
方法： 通过PubMed、EMBASE、Web of Science、Cochrane Library、CNKI和万方数据库检索文献。对截至2026年5月20日发表的9项研究进行了荟萃分析，并使用STATA16.0进行统计分析。通过计算合并比值比（OR）及相应的95%置信区间（95% CI）定量评估产前母亲应激与子代AR之间的关联。通过漏斗图以及Egger's和Begg's检验评估潜在的发表偏倚。
结果： 经过系统性文献筛选，共纳入9项研究，涉及40,630名参与者。荟萃分析显示，产前母亲应激与子代AR风险增加显著相关（OR = 1.69，95% CI：1.51-1.86，P < 0.001，I2 = 47.78%）。按应激类型进行的分层分析显示出梯度效应：产前焦虑的AR风险最低（OR = 1.42，95% CI：1.20-1.63，P < 0.001，I2 = 42.67%），其次为抑郁（OR = 1.61，95% CI：1.40-1.82，P < 0.001，I2 = 54.74%），而应激性生活事件最高（OR = 1.74，95% CI：1.29-2.18，P < 0.001，I2 = 70.04%）。
结论： 产前母亲应激可增加儿童AR的风险。孕期经历的各种类型母亲应激对儿童随后发生过敏性鼻炎的可能性呈现出显著的梯度效应。
英文摘要
BACKGROUND: Prenatal maternal stress influences the development of the fetal immune system and may increase the risk of allergic rhinitis (AR) in childhood. This meta-analysis provides a systematic assessment of the relationship between maternal stress during pregnancy and the subsequent occurrence of AR in offspring.
OBJECTIVE: To explore the relationship between prenatal maternal stress and the risk of AR in offspring.
METHODS: Articles were searched by using PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, and Wanfang databases. A meta-analysis was performed on 9 studies published up to May 20th, 2026, was conducted for statistical analysis with STATA16.0. The association between prenatal maternal stress and offspring AR was quantitatively assessed by calculating pooled odds ratio (OR) with corresponding 95% confidence interval (95% CI). Potential publication bias was assessed through funnel plots as well as Egger's and Begg's tests.
RESULTS: A total of 9 studies involving 40,630 participants were included after systematic literature screening. Meta-analysis showed that prenatal maternal stress was significantly associated with an increased risk of AR in offspring (OR = 1.69, 95% CI:1.51-1.86, P < 0.001, I2 = 47.78%). Stratified analysis by stress type showed a gradient effect: the risk of AR was lowest for prenatal anxiety (OR = 1.42, 95% CI:1.20-1.63, P < 0.001, I2 = 42.67%), followed by depression (OR = 1.61, 95%CI:1.40-1.82, P < 0.001, I2 = 54.74%), and highest for stressful life events (OR = 1.74, 95% CI:1.29-2.18, P < 0.001, I2 = 70.04%).
CONCLUSIONS: Prenatal maternal stress can increase the risk of AR in children. Various types of maternal stress experienced during pregnancy exhibit a notable gradient effect on the likelihood of children developing allergic rhinitis subsequently.