有其父必有其女：一名女性患者及其父亲发生阿莫西林诱导的无菌性脑膜炎：一例病例报告。
Like father, like daughter: amoxicillin-induced aseptic meningitis in a female patient and her father: a case report.
文献信息
| PMID | 42760564 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Ibrahim Farhood |
| 作者单位 | Department of Neurology, Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, In Der Schornau 23-25, 44892, Bochum, Germany. ibrahim.farhood@knappschaft-kliniken.de. |
| 期刊 | Journal of medical case reports |
| SCI 分区 | Q3 |
| IF | 0.9 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
背景： 药物诱导的无菌性脑膜炎（DIAM）是一种神经系统疾病，需要专门的诊断路径和深入的患者病史采集，以防止不准确的诊断和不必要的操作。阿莫西林已被报道为引起复发性DIAM的药物之一，文献中总共描述了22例患者。
病例介绍： 我们报告了两例涉及地中海族裔患者的病例——一位父亲（69岁）及其女儿（47岁）——他们在不同时间点因持续数日的严重头痛就诊于我们的神经内科。两位患者均透露近期使用阿莫西林治疗支气管炎和耳炎。在两例病例中，脑脊液（CSF）检查显示以淋巴细胞为主的白细胞增多，而未鉴定出致病病原体。在进行了广泛检查以排除继发性头痛的其他原因后，确立了阿莫西林诱导的无菌性脑膜炎（AIAM）的诊断。值得注意的是，女儿经历了两次类似的发作，均与阿莫西林摄入在时间上相关。
结论： 阿莫西林诱导的无菌性脑膜炎是一种罕见的不良反应，在无明确病原体的情况下出现严重头痛的患者中应考虑该诊断。全面的患者病史采集结合综合诊断评估对于确立诊断和避免不必要或过度的治疗至关重要。此外，如其他形式的药物诱导的无菌性脑膜炎所提示的，潜在的遗传易感性可能发挥作用，在特定病例中应考虑。
英文摘要
BACKGROUND: Drug-induced aseptic meningitis (DIAM) is a neurological disorder that requires specialized diagnostic pathways and an in-depth patient history to prevent inaccurate diagnoses and unnecessary procedures. Amoxicillin has been reported as one of the drugs causing recurrent DIAM, with a total of 22 patients described in the literature.
CASE PRESENTATION: We report two cases involving patients of Mediterranean ethnicity -a father (69-years-old) and his daughter (47-years-old)-who presented to our neurology department at different time points with severe headache persisting for several days. Both patients disclosed recent use of amoxicillin to treat bronchitis and otitis. In both cases, examination of cerebrospinal fluid (CSF) revealed leukocytosis with lymphocytic predominance, while no causative pathogens were identified. After extensive investigations to rule out other causes of secondary headache, a diagnosis of amoxicillin-induced aseptic meningitis (AIAM) was established. Notably, the daughter experienced two similar episodes, both temporally associated with amoxicillin intake.
CONCLUSIONS: Amoxicillin-induced aseptic meningitis is a rare adverse reaction that should be considered in patients presenting with severe headache in the absence of an identifiable pathogen. A thorough patient history combined with comprehensive diagnostic evaluation is essential to establish the diagnosis and to avoid unnecessary or excessive treatment. Additionally, potential genetic predispositions, as suggested in other forms of drug-induced aseptic meningitis, may play a role and should be considered in selected cases.