Article record

累及耳部及耳周区域的婴儿血管瘤的临床特征、治疗及并发症。

Clinical Characteristics, Management, and Complications of Infantile Hemangiomas Involving the Ear and Periauricular Region.

临床研究耳科IF 1.4Q3

文献信息

PMID	42751730
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Bayan Matarneh 查看其他 17 位作者 Nicole Stefanko；Anthony J Mancini；Sarah L Chamlin；Catherine C McCuaig；Julie Powell；Maxine Joly-Chevrier；Erin F D Mathes；Ilona J Frieden；Mitchell Braun；Maria C Garzon；Kimberly D Morel；Christine T Lauren；Kimberly A Horii；Brandon Newell；Sonal D Shah；Amy Buros-Stein；Esteban Fernandez Faith
作者单位	Nationwide Children's Hospital and the Ohio State University College of Medicine, Columbus, Ohio, USA. 查看其他 7 条单位信息 Ann & Robert H. Lurie Children's Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.；Center Hospitalier Universitaire (CHU) Sainte-Justine, Montréal, Quebec, Canada.；University of California, San Francisco School of Medicine, San Francisco, California, USA.；Columbia University, New York, New York, USA.；Children's Mercy Kansas City, Kansas City, Missouri, USA.；University Hospitals, Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.；Pediatric Dermatology Research Alliance (PeDRA) Biostatistics Core, Portland, Oregon, USA.
期刊	Pediatric dermatology
SCI 分区	Q3
IF	1.4
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

背景： 尽管不同解剖部位的婴儿血管瘤（IH）研究取得了进展，但针对累及耳部及耳周区域的IH研究仍然很少。
目的： 分析累及耳部及耳周区域的IH的临床特征、治疗及结局。
方法： 多中心回顾性研究，纳入2001年至2021年间在七个三级转诊中心就诊的累及耳部及耳周区域的IH患者。分析的数据包括患者人口统计学资料、IH位置、治疗实践、血管瘤严重程度量表（HSS）评分以及美国儿科学会（AAP）IH风险分类。
结果： 共有305名患者符合纳入标准。250名患者有治疗决策信息。在有治疗信息的患者中，80%采取了积极干预。解剖畸形风险是最常见的治疗指征（72%），其次是溃疡（18%）和功能受损风险（17%）。48%的患者使用了全身性β受体阻滞剂，其次是局部皮质类固醇（46%）和局部噻吗洛尔（32%）。与接受局部治疗的患者（中位数10，IQR：8-12）相比，接受全身性β受体阻滞剂治疗的患者HSS评分显著更高（中位数15.5，IQR：12-20）。
结论： 鉴于其位置以及可能导致解剖畸形和功能受损，耳部及耳周IH可能需要干预。该队列中大多数患者需要治疗，最常见的原因是解剖畸形风险。该研究受限于回顾性设计以及纳入了在β受体阻滞剂可用于IH治疗之前就诊的患者。

英文摘要

BACKGROUND: Despite advances in IH research across various anatomical sites, studies focusing on IH involving the ear and periauricular areas remain scarce.
OBJECTIVE: To analyze the clinical characteristics, management, and outcomes of IH involving the ear and periauricular area.
METHODS: Multicenter, retrospective study of patients with IH involving the ear and periauricular area across seven tertiary referral centers between 2001 and 2021. Data analyzed included patient demographics, IH location, management practices, Hemangioma Severity Scale (HSS) scores, and American Academy of Pediatrics (AAP) IH risk categories.
RESULTS: A total of 305 patients met the inclusion criteria. Management decision information was available in 250 patients. Active intervention was pursued in 80% of the patients with available management information. The risk of anatomic deformity was the most common indication for treatment (72%), followed by ulceration (18%) and the risk of functional impairment (17%). Systemic beta-blockers were used in 48% of patients, followed by topical corticosteroids (46%) and topical timolol (32%). Treatment with a systemic beta-blocker was associated with a significantly higher HSS score (median 15.5, IQR: 12-20) compared to patients treated with topical therapy (median 10, IQR: 8-12).
CONCLUSIONS: Given their location and potential for anatomic deformity and functional impairment, ear and periauricular IH may require intervention. A majority of patients in this cohort required treatment, most commonly for risk of anatomic deformity. The study is limited by the retrospective design and inclusion of patients seen before beta-blockers were available for IH management.