耳鼻喉科Pubmed文献追踪每日 14:00 同步
← 返回全部文献
Article record

0-12岁儿童鼓膜置管插入趋势：丹麦基于登记的队列研究（2003-2023年）

Trends in Tympanostomy Tube Insertion Among Children Aged 0-12 Years: A Register-Based Cohort Study in Denmark (2003-2023).

临床研究耳科IF 4.8Q1

文献信息

PMID42751577
原文在 PubMed 查看原文 ↗
发表日期2026
作者Michael Lüscher
查看其他 7 位作者

Nikolaj B Pedersen；Steven A W Andersen；Thomas Qvist Barrett；Peter Tingsgaard；Lene Dahl Siggaard；Per Kallestrup；Anders Prior

作者单位Research Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark.
查看其他 5 条单位信息

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.；Ear, Nose, and Throat Practice, Randers, Denmark.；Ear, Nose, and Throat Practice, Slagelse, Denmark.；Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.；Department of Public Health, Aarhus University, Aarhus, Denmark.

期刊Clinical epidemiology
SCI 分区Q1
IF4.8
研究类型临床研究 · 临床
所属专科耳科

中文摘要

目的： 鼓膜置管插入（TTI）是儿童中最常实施的外科手术之一。然而，在可比较的医疗保健系统之间，仍存在显著的时间和地理差异。我们旨在描述2003-2023年丹麦儿童中TTI的全国趋势，特别关注与COVID-19大流行相关的变化以及治疗模式的地区差异。
患者与方法： 在这项全国性基于登记的队列研究中，我们纳入了2003年至2023年间所有0-12岁的丹麦儿童（n=2,243,285）。TTI数据来自丹麦国家患者登记处和丹麦国家健康服务登记处。使用日历年度和出生队列分析了发病率、累积比例、首次手术年龄和地区差异。
结果： 我们识别出在371,818名儿童中实施的704,013例TTI手术；96.6%在耳鼻喉（ENT）诊所进行。年度手术数量在2010年达到峰值40,826例，并稳步下降至2019年的29,846例。2020-2021年COVID-19大流行期间出现显著减少，随后在2022年反弹至大流行前水平，并在2023年进一步增加至35,024例手术。至少接受一次TTI的儿童比例从2019年的3.11%上升至2023年的3.67%（比例比（PR）1.18，95%置信区间（CI）1.16-1.20）。首次TTI的中位年龄为18.1个月，地区差异持续存在；北丹麦地区发生率最高，丹麦首都地区最低。
结论： 过去十年中，丹麦儿童的TTI发生率大幅下降，在COVID-19大流行期间进一步下降，随后恢复至大流行前水平。持续存在的地区差异表明临床实践存在差异，这不能仅由 underlying disease epidemiology 解释。大流行对TTI利用的长期影响仍不确定。

英文摘要

PURPOSE: Tympanostomy tube insertion (TTI) is one of the most frequently performed surgical procedures in children. Yet, substantial temporal and geographical variations persist across comparable healthcare systems. We aimed to describe nationwide trends in TTI among Danish children in 2003-2023, with particular attention to changes associated with the COVID-19 pandemic and regional differences in treatment patterns.
PATIENTS AND METHODS: In this nationwide register-based cohort study, we included all Danish children aged 0-12 years between 2003 and 2023 (n=2,243,285). Data on TTIs were obtained from the Danish National Patient Register and the Danish National Health Service Register. Incidence rates, cumulative proportions, age at first procedure, and regional variation were analyzed using calendar year and birth cohorts.
RESULTS: We identified 704,013 TTI procedures performed in 371,818 children; 96.6% were conducted in ear, nose, and throat (ENT) practices. Annual procedure numbers peaked at 40,826 cases in 2010 and declined steadily to 29,846 cases in 2019. A marked reduction occurred during the COVID-19 pandemic in 2020-2021, followed by a rebound to the pre-pandemic level in 2022 and a further increase to 35,024 procedures in 2023. The proportion of children receiving at least one TTI increased from 3.11% in 2019 to 3.67% in 2023 (proportion ratio (PR) 1.18, 95% confidence interval (CI) 1.16-1.20). Median age at first TTI was 18.1 months, with persistent regional variation; rates were highest in the North Denmark Region and lowest in the Capital Region of Denmark.
CONCLUSION: TTI rates in Danish children decreased substantially over the past decade, declined further during the COVID-19 pandemic, and subsequently returned to pre-pandemic levels. Persistent regional differences indicate variation in clinical practice that cannot be explained solely by underlying disease epidemiology. The long-term effects of the pandemic on TTI utilization remain uncertain.