前庭性偏头痛与梅尼埃病中的全身免疫炎症指数和预后营养指数：与健康对照的回顾性比较
Systemic immune-inflammation index and prognostic nutritional index in vestibular migraine and Meniere's disease: a retrospective comparison with healthy controls.
文献信息
| PMID | 42747533 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Halil Elden |
| 作者单位 | Department of Otorhinolaryngology, Sakarya University Training and Research Hospital, Sakarya, Turkey. eldenhalil@gmail.com. |
| 期刊 | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery |
| SCI 分区 | Q1 |
| IF | 2.3 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 探讨前庭性偏头痛（VM）患者、梅尼埃病（MD）患者与健康对照之间全身免疫炎症指数（SII）和预后营养指数（PNI）是否存在差异，并检验其与年度眩晕发作频率及头晕相关残疾的关联。
方法： 这项基于病历的回顾性比较研究纳入了100例确诊VM患者、100例确诊MD患者和100例健康对照。对于VM组和MD组，SII和PNI根据通过回顾性筛查眩晕门诊记录获取的常规发作间期血液检测结果计算。关联采用Spearman相关性分析评估；并根据情况采用年龄和性别校正的线性回归或Poisson回归。使用Benjamini-Hochberg法控制错误发现率（FDR）。
结果： PNI和SII在VM组、MD组和对照组之间无差异。VM的年度发作次数高于MD（p = 0.004，q = 0.048）。在FDR校正后，16项探索性相关性分析均未保持显著。MD中PNI与发作次数之间的名义负相关（rho = -0.221，p = 0.027）其q = 0.415，且在校正模型中，PNI和SII均与DHI或发作次数无独立关联（所有q ≥ 0.507）。
结论： 以阴性为主的发现不支持将SII或PNI作为发作间期VM或MD的独立诊断或严重程度标志物，尽管不能排除低于本研究检测阈值的微小效应。在考虑任何临床作用之前，需要进行具有连续测量和发作期测量的前瞻性研究。
英文摘要
PURPOSE: To investigate whether the systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) differ among patients with vestibular migraine (VM), patients with Meniere's disease (MD), and healthy controls, and to examine their associations with annual vertigo attack frequency and dizziness-related disability.
METHODS: This retrospective record-based comparative study included 100 patients with definite VM, 100 patients with definite MD, and 100 healthy controls. For the VM and MD groups, SII and PNI were derived from routine interictal blood test results retrieved through retrospective screening of vertigo outpatient clinic records. Associations were evaluated using Spearman correlations; age and sex adjusted linear or Poisson regression, as appropriate. The Benjamini-Hochberg procedure was used to control the false discovery rate (FDR).
RESULTS: PNI and SII did not differ among VM, MD, and control groups. Annual attack count was higher in VM than in MD (p = 0.004, q = 0.048). None of the 16 exploratory correlations remained significant after FDR correction. The nominal inverse correlation between PNI and attack count in MD (rho = - 0.221, p = 0.027) had q = 0.415, and neither PNI nor SII was independently associated with DHI or attack count in the adjusted models (all q ≥ 0.507).
CONCLUSION: The predominantly negative findings do not support SII or PNI as stand-alone diagnostic or severity markers for interictal VM or MD, although small effects below the study's detection threshold cannot be excluded. Prospective studies with serial and attack-phase measurements are needed before any clinical role can be considered.