C4硬膜外电刺激通过上行脊髓和周围反馈通路改变舌下运动输出
Hypoglossal motor output is altered by C4 epidural electrical stimulation via ascending spinal and peripheral feedback pathways.
文献信息
| PMID | 42747377 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Alyssa R Mickle |
| 作者单位 | Department of Neuroscience, University of Florida, 1149 Newell Dr, Gainesville, FL 32610. |
| 期刊 | Journal of neurophysiology |
| SCI 分区 | Q3 |
| IF | 2.8 |
| 研究类型 | 基础研究 · 基础／转化 |
| 所属专科 | 咽喉科 |
中文摘要
颈段脊髓损伤（cSCI）后，上气道功能障碍非常普遍，包括阻塞性睡眠呼吸暂停和吞咽功能障碍的发生率显著增加。虽然这些缺陷常被归因于继发性来源，如损伤管理并发症造成的损害或解剖结构改变，但近来人们越来越认识到脊髓群体在上气道行为中的调节作用，而这些行为会被损伤所破坏。在此，我们在cSCI啮齿动物模型中表明，对C4脊髓节段膈运动核进行硬膜外脊髓刺激（ESS）可通过激活兴奋性上行脊髓通路和抑制性周围感觉反馈机制，改变舌下运动核的运动输出。这些发现强调了脊髓-脑干通讯在塑造上气道肌肉运动程序中的重要性，并提示刺激颈段脊髓可能是脊髓损伤后增强上气道运动输出的可行治疗靶点。
英文摘要
After cervical spinal cord injury (cSCI), upper airway dysfunction is highly prevalent, including a dramatically increased incidence of obstructive sleep apnea and swallowing dysfunction. While these deficits have often been attributed to secondary sources such as damage from complications of injury management or anatomical changes, there has recently been a greater appreciation for the modulatory role of spinal populations in upper airway behaviors that are disrupted by injury. Here, we illustrate in a rodent model of cSCI that epidural spinal stimulation (ESS) of the phrenic motor nucleus at spinal segment C4 alters motor output at the hypoglossal motor nucleus through activation of excitatory ascending spinal pathways and inhibitory peripheral sensory feedback mechanisms. These findings highlight the importance of spinal-brainstem communication in shaping the motor program of upper airway musculature and suggest that stimulation of the cervical spinal cord may be a viable therapeutic target for augmenting upper airway motor output after spinal injury.