Article record

年龄相关性听力损失治疗的进展：从分子机制到靶向干预

Advances in the treatment of age-related hearing loss: from molecular mechanisms to targeted interventions.

综述 Meta耳科IF 5.6Q1

文献信息

PMID	42746317
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Le Mao 查看其他 7 位作者 Sijie Ma；Kun Zhu；Chao Feng；Xinyu Chen；Fangli Yang；Maoli Duan；Xiaowan Chen
作者单位	The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China. 查看其他 4 条单位信息 Department of Otolaryngology Head and Neck Surgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu, China.；Department of Otolaryngology Head and Neck Surgery & Audiology and Neurotology, Karolinska University Hospital, Stockholm, Sweden.；ENT Division, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.；Department of Otolaryngology Head and Neck Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
期刊	Frontiers in aging neuroscience
SCI 分区	Q1
IF	5.6
研究类型	综述 Meta · 基础／转化
所属专科	耳科

中文摘要

年龄相关性听力损失（ARHL）是老年人中最常见的感觉障碍。当前的听力干预措施，包括助听器和人工耳蜗，在可及性和依从性方面面临局限。因此，人们致力于阐明耳蜗老化的分子机制，并确定ARHL的有效治疗靶点。本综述总结了与耳蜗老化和ARHL相关的几种分子机制，包括自噬失调、氧化应激、静纤毛变性和线粒体动力学失调。我们进一步讨论了与这些通路相关的潜在治疗靶点和干预策略的最新进展，并为ARHL的靶向干预提供理论支持。

英文摘要

Age-related hearing loss (ARHL) is the most common sensory disorder in older adults. Current hearing interventions, including hearing aids and cochlear implants, face limitations in accessibility and adherence. Therefore, efforts have been devoted to elucidating the molecular mechanisms underlying cochlear aging and identifying effective therapeutic targets for ARHL. This review summarizes several molecular mechanisms implicated in cochlear aging and ARHL, including autophagy dysregulation, oxidative stress, stereocilia degeneration, and dysregulation of mitochondrial dynamics. We further discuss recent advances in potential therapeutic targets and intervention strategies associated with these pathways, and provide theoretical support for targeted interventions for ARHL.