多囊卵巢综合征与主观及客观睡眠质量评估：系统综述与荟萃分析。
Polycystic Ovary Syndrome and Subjective and Objective Assessments of Sleep Quality: A Systematic Review and Meta-Analysis.
文献信息
| PMID | 42746131 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Arefeh Tabashiri |
| 作者单位 | Reproductive Endocrinology Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran. |
| 期刊 | Health science reports |
| SCI 分区 | Q1 |
| IF | 2.6 |
| 研究类型 | 综述 Meta · 临床 |
| 所属专科 | 耳科 |
中文摘要
背景与目的： 多囊卵巢综合征（PCOS）女性的睡眠障碍日益受到认识，但证据仍不一致。我们进行了一项荟萃分析，以评估PCOS女性的客观睡眠异常和主观睡眠主诉。
方法： 我们系统回顾并荟萃分析了比较PCOS女性与非PCOS女性的观察性研究。主要结局是通过多导睡眠图评估的客观睡眠参数，次要结局包括使用经过验证的问卷（包括Epworth嗜睡量表（ESS）和匹兹堡睡眠质量指数（PSQI））测量的主观睡眠质量和日间嗜睡。
结果： 共纳入21项研究，涉及1,255名PCOS女性和1,523名对照。与对照组相比，PCOS女性的呼吸暂停低通气指数显著更高（SMD=1.030，95% CI：0.408至1.653，p=0.001）。此外，与对照组相比，PCOS女性在PSQI和ESS问卷上的得分均显著更高（SMD：0.435；95% CI：0.190至0.680，p=0.001；以及SMD：1.263；95% CI：0.335至2.191，p=0.008）。荟萃分析显示PCOS组的1期睡眠更长（SMD：2.356；95% CI：0.224至4.488，p=0.03）。然而，REM睡眠、2期睡眠以及3期和4期睡眠在两组之间没有显著差异。
结论： 本研究强调了PCOS女性与对照组之间在某些睡眠呼吸障碍指数、睡眠结构和客观睡眠质量指标上存在显著差异。主观睡眠指标显示出比某些客观评估更明显的差异，表明对感知到的睡眠障碍有更大的影响。
英文摘要
BACKGROUND AND AIMS: Sleep disturbances are increasingly recognized in women with polycystic ovary syndrome (PCOS), but the evidence remains inconsistent. We conducted a meta-analysis to evaluate objective sleep abnormalities and subjective sleep complaints in women with PCOS.
METHODS: We systematically reviewed and meta-analyzed observational studies comparing women with PCOS and women without PCOS. Primary outcomes were objective sleep parameters assessed by polysomnography, while secondary outcomes included subjective sleep quality and daytime sleepiness measured using validated questionnaires, including the Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI).
RESULTS: Twenty-one studies involving 1,255 women with PCOS and 1,523 controls were included. Women with PCOS had a significantly higher apnea-hypopnea index compared to controls (SMD = 1.030, 95% CI: 0.408 to 1.653, p = 0.001). Additionally, women with PCOS exhibited significantly higher scores on both PSQI and ESS questionnaires compared to the control group (SMD: 0.435; 95% CI: 0.190 to 0.680, p = 0.001, and SMD: 1.263; 95% CI: 0.335 to 2.191, p = 0.008, respectively). Meta-analysis demonstrated longer stage 1 sleep in PCOS group (SMD: 2.356; 95% CI: 0.224 to 4.488, p = 0.03). However, REM sleep, stage 2, and stages 3 and 4 showed no significant differences between groups.
CONCLUSION: This study highlights significant differences in some sleep-disordered breathing indices, sleep structure, and objective sleep quality measures between women with PCOS and control groups. Subjective sleep measures demonstrated more pronounced differences than some objective assessments, suggesting a greater impact on perceived sleep disturbances.