临床与自报听力测量指标及痴呆风险
Clinical and self-reported hearing measures and dementia risk.
文献信息
| PMID | 42744782 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Abigail Dichter |
| 作者单位 | Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA. |
| 期刊 | Journal of Alzheimer's disease : JAD |
| SCI 分区 | Q2 |
| IF | 4.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
本研究在一个大型人群队列中评估了听力损失（HL）作为与痴呆相关因素的作用。我们分析了来自All of Us数据库的16,270名参与者，其中包括1224名（7.5%）痴呆患者，并按美国人口普查人口学特征与对照匹配。自报严重听力困难与痴呆的关联最强（OR 6.76），其次是感音神经性听力损失（SNHL）（OR 3.90）、吸烟（OR 1.71）、父母听力损失（OR 1.48）和高血压（OR 1.48），所有p < 0.001。效应量最大的是自报严重听力困难（1.91）和SNHL（1.36）。这些发现表明，自报严重听力困难和SNHL与痴呆密切相关。
英文摘要
This study evaluated hearing loss (HL) as a factor associated with dementia in a large population-based cohort. We analyzed 16,270 participants from the All of Us database, including 1224 (7.5%) with dementia, matched to controls by U.S. census demographics. Self-reported severe hearing difficulty showed the strongest association with dementia (OR 6.76), followed by sensorineural HL (SNHL) (OR 3.90), smoking (OR 1.71), parental HL (OR 1.48), and hypertension (OR 1.48), all p < 0.001. Effect sizes were largest for self-reported severe hearing difficulty (1.91) and SNHL (1.36). These findings indicate that self-reported severe hearing difficulty and SNHL are strongly associated with dementia.