膳食摄入酶解蜂幼虫可减轻小鼠进行性噪声性听力损伤

文献信息

中文摘要

蜂幼虫（BL）作为传统药物和食品有着悠久的使用历史。鉴于蜂幼虫含有抗炎脂质和免疫调节成分，它们可能对听力损失和耳鸣有效。在本研究中，我们利用急性声损伤和噪声性听力损失（NIHL）的小鼠模型，研究了酶解蜂幼虫对抑制听力损失的作用。在C57BL/6小鼠暴露于单次5分钟110 dB白噪声的实验中，发现蜂幼虫预处理可减少暂时性声损伤。此外，在重复10分钟噪声暴露以诱导NIHL的条件下，食用酶解蜂幼虫可减轻听力损伤的进展。此外，在酶解蜂幼虫中证实了抗氧化活性。细胞实验和己烷提取物组分的分析表明，蜂幼虫可减少内耳中噪声诱导的氧化应激。总之，这些发现表明酶解蜂幼虫对听力损失的进展发挥保护作用。

英文摘要

Bee larvae (BL) have a long history of use as both traditional medicine and food. Given that BL contain anti-inflammatory lipids and immune-modulating components, they may be efficacious against hearing loss and tinnitus. In this study, we investigated the effects of enzymatically processed BL on the suppression of hearing loss using mouse models of acute acoustic injury and noise-induced hearing loss (NIHL). In an assay where C57BL/6 mice were exposed to a single 5-min burst of 110 dB white noise, pre-treatment with BL was found to reduce transient acoustic damage. Furthermore, under conditions of repeated 10-min noise exposures to induce NIHL, consumption of enzymatically processed BL mitigated the progression of hearing impairment. Additionally, antioxidant activity was confirmed in the enzymatically processed BL. Cellular assays and analysis of hexane extract fractions suggested that BL reduces noise-induced oxidative stress in the inner ear. Collectively, these findings demonstrate that enzymatically processed BL exert protective effects against the progression of hearing loss.