肠-耳轴：从菌群失调到听觉和前庭疾病

文献信息

中文摘要

随着对肠道微生物群与人类健康关系研究的深入，关于各种肠-X轴的讨论日益普遍。有证据表明，微生物群失调与听觉前庭疾病的发生和进展密切相关，肠-耳轴已逐渐被认为是一条重要的全身性调节通路。本文系统综述了微生物群失调与听觉前庭疾病之间的相互作用机制、干预策略、研究局限性和未来展望。该轴主要通过免疫介导的屏障损伤、代谢紊乱和神经递质串扰发挥作用。调节肠道微生物群可以缓解某些听觉前庭疾病的症状。本综述旨在为听觉前庭疾病的发病机制、干预和临床管理提供新的见解。

英文摘要

With further research on the relationship between gut microbiota and human health, discussions on various gut-X axis have been increasingly prevalent. Evidence indicates that microbiota dysbiosis is closely linked to the onset and progression of audiovestibular disorders and the gut-ear axis has gradually been recognized as a vital systemic regulatory pathway. This article systematically reviewed the interaction mechanisms between microbiota dysbiosis and audiovestibular diseases, intervention strategies, research limitations and future perspectives. This axis functions mainly through immune-mediated barrier damage, metabolic disorder and neurotransmitter crosstalk. Modulation of the gut microbiota can alleviate symptoms of certain audiovestibular disorders. This review aims to provide novel insights for the pathogenesis, intervention and clinical management of audiovestibular disorders.