晚期肺癌炎症指数与阻塞性睡眠呼吸暂停中高血压的关联
Association of advanced lung cancer inflammation index with hypertension in obstructive sleep apnea.
文献信息
| PMID | 42736731 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Mengying Lin |
| 作者单位 | Department of Psychosomatic, Shaoxing Seventh People's Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China. |
| 期刊 | Medicine |
| SCI 分区 | Q2 |
| IF | 2.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 阻塞性睡眠呼吸暂停（OSA）与高血压之间的关系已得到充分证实。晚期肺癌炎症指数（ALI）整合了炎症和营养状况的标志物，已被发现与OSA患者的高血压相关。本研究旨在探讨OSA患者中ALI与高血压之间的关联。方法：分析了来自四个国家健康与营养调查（NHANES）周期的12,049名参与者的数据。OSA通过基于问卷的睡眠相关信息进行识别。采用调整混杂因素的逻辑回归模型和限制性立方样条（RCS）分析来评估关联及潜在的非线性关系。结果：逻辑回归分析显示，Log ALI每增加一个单位，高血压的比值比更高（OR=1.44，95% CI：1.25-1.66，P<0.001）。四分位数分析表明，ALI第四四分位数的参与者比最低四分位数的参与者有更高的高血压比值比（OR=1.70，95% CI：1.40-2.07，P<0.001）。RCS分析支持ALI与高血压之间的非线性关联。结论：本研究表明，在OSA患者中，ALI与高血压之间存在显著关联，突出了炎症和营养状况在高血压中的潜在相关性。
英文摘要
The relationship between obstructive sleep apnea (OSA) and hypertension has been well established. The Advanced Lung Cancer Inflammation Index (ALI), which integrates markers of inflammation and nutritional status, has been associated with hypertension in OSA patients. This study aimed to explore the association between ALI and hypertension among individuals with OSA. Data from 12,049 participants across four National Health and Nutrition Examination Survey (NHANES) cycles were analyzed. OSA was identified using a questionnaire-based sleep-related information. Logistic regression models adjusted for confounders and restricted cubic spline (RCS) analyses were conducted to evaluate the associations and potential nonlinear relationships. Logistic regression analysis showed that each unit increase in Log ALI was associated with higher odds of hypertension (OR = 1.44, 95% CI: 1.25-1.66, P < .001). Quartile analysis demonstrated that participants in the fourth ALI quartile had higher odds of hypertension than those in the lowest quartile (OR = 1.70, 95% CI: 1.40-2.07, P < .001). RCS analysis supported the nonlinear association between ALI and hypertension. This study suggests a significant association between ALI and hypertension in individuals with OSA, highlighting the potential relevance of inflammation and nutritional status in hypertension.