Robin序列的听力学表现：系统综述与Meta分析

文献信息

中文摘要

目的： 综合现有关于Robin序列（RS）患者听力学表现的证据。设计：本系统综述按照系统综述和Meta分析首选报告条目声明进行，并在PROSPERO注册（CRD 42024581313）。环境：检索多个数据库，包括Cochrane图书馆、Embase、PubMed/MEDLINE、Scopus、Virtual Health Library和Web of Science，以及灰色文献（Google Scholar和ProQuest）。考虑纳入以巴西葡萄牙语、英语或西班牙语发表的实验性和观察性研究，不限地点或发表时间。患者：RS患者，伴或不伴腭裂（CP），性别不限，年龄不限。主要结局指标：听力学结局指标。结果：共识别644条记录，其中289条为重复。筛选355篇标题和摘要后，排除346项研究，纳入9项。总体偏倚风险低。对3项研究的Meta分析显示，与对照组相比，RS伴CP患者发生听力损失的比值比更高（比值比=2.49；95%置信区间：1.24-5.00），研究间无异质性。证据确定性低。结论：听力损失是RS患者的常见表现，主要为传导性，程度从轻度到中度，并且在伴有CP的患者中更常见。这些发现强调需要持续进行听力学评估和监测，以及实施标准化临床方案。需要方法学更严谨的进一步研究，以加强证据基础并指导临床实践。

英文摘要

ObjectiveTo synthesize the available evidence on audiological findings in individuals with Robin sequence (RS).DesignThis systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and registered in PROSPERO (CRD 42024581313)SettingSearches were conducted across multiple databases, including the Cochrane Library, Embase, PubMed/MEDLINE, Scopus, Virtual Health Library, and Web of Science, as well as gray literature (Google Scholar and ProQuest). Experimental and observational studies published in Brazilian Portuguese, English, or Spanish were considered eligible, with no restrictions on location or publication date.PatientsIndividuals with RS, with or without cleft palate (CP), of either sex and with no age restrictions.Main Outcome Measure(s)Audiological outcome measures.ResultsA total of 644 records were identified, of which 289 were duplicates. After screening 355 titles and abstracts, 346 studies were excluded, and 9 were included. The overall risk of bias was low. A meta-analysis of 3 studies showed higher odds of hearing loss in individuals with RS and CP compared with the control group (odds ratio = 2.49; 95% confidence interval: 1.24-5.00), with no heterogeneity among studies. The certainty of the evidence was low.ConclusionsHearing loss was a frequent finding in individuals with RS, predominantly conductive and ranging from mild to moderate degrees, and was more frequently observed in those with CP. These findings highlight the need for continuous audiological assessment and monitoring, as well as the implementation of standardized clinical protocols. Further studies with greater methodological rigor are required to strengthen the evidence base and inform clinical practice.