帕金森病和多系统萎缩早期阶段的言语声门流表现

文献信息

中文摘要

言语发声子系统已被广泛研究，用于评估多种病理情况下的发声障碍，尤其是神经退行性疾病。扰动和/或倒谱测量一直是用于此目的的传统声学特征。然而，这些测量方法的缺点在于涉及所有言语产生子系统。为了分离发声成分，分析由声带振动产生的声门流是一种有吸引力的替代方法。然而，尽管其具有显著的相关性，这种方法的研究相对较少。在本文中，我们进行了首项关于非典型帕金森综合征中声门流表现的研究。我们的主要目标是识别能够帮助解决帕金森病（PD）和多系统萎缩帕金森变异型（MSA-P）之间早期鉴别诊断这一挑战性问题的独特声门特征。除了传统的持续发声任务外，我们还分析了在轮替运动（DDK）任务中的短元音产生，使用了一种经典的声门流估计和参数化方法。结果表明，DDK任务对于揭示MSA-P特异性的声门中断具有价值。此外，与其他研究相反，我们的结果表明早期PD患者并未表现出声门流损伤。

英文摘要

The speech phonation subsystem has been widely studied for assessing phonatory impairments in the presence of numerous pathologies, especially neurodegenerative diseases. Perturbation or/and cepstral measures have been the traditional acoustic features for this purpose. However, these measures have the drawback of involving all the speech production subsystems. To isolate the phonatory component, analysis of the glottal flow generated by the vibration of the vocal folds is an appealing alternative. However, despite its significant pertinence, this approach has been relatively little studied. In this paper, we conducted the first study of glottal flow performance in the setting of atypical parkinsonian disorders. Our main objective was the identification of distinctive glottal features that can assist in the challenging problem of early differential diagnosis between Parkinson's disease (PD) and the parkinsonian variant of multiple systems atrophy (MSA-P). In addition to the traditional sustained phonation task, we analyzed short vowel production in diadochokinesis (DDK) tasks, using a classical method for the estimation and parameterization of the glottal flow. The results showed that the DDK task was valuable towards revealing MSA-P specific glottal disruptions. Moreover, contrarily to other studies, our results suggested that patients with early-stage PD do not manifest glottal flow impairment.