听力损失与中老年晚期队列中的区域性大脑淀粉样蛋白相关
Hearing Loss Is Associated With Regional Brain Amyloid in a Late Middle-Aged Cohort.
文献信息
| PMID | 42732997 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | S Dillon Powell |
| 作者单位 | Department of Otolaryngology-Head and Neck Surgery, Vagelos College of Physicians and Surgeons, NewYork-Presbyterian, Columbia University Irving Medical Center, Columbia University, New York, New York, USA. |
| 期刊 | The Laryngoscope |
| SCI 分区 | Q2 |
| IF | 2.3 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 研究听力损失（HL），通过较好耳的纯音平均听阈（PTA）和言语识别率（WRS）测量，与通过淀粉样蛋白正电子发射断层扫描（PET）测量的脑淀粉样蛋白沉积之间的关联。
方法： 纳入223名参与者。主要结局包括PET上的全脑和区域淀粉样蛋白标准化摄取值比（SUVR）。主要暴露因素为PTA和WRS。使用控制相关协变量的多变量线性回归。
结果： 参与者的平均年龄（标准差）为65.6（3.8）岁，平均PTA为21.0（8.5）dB。在完全调整模型中，PTA每恶化（增加）10 dB，左侧颞叶区域的淀粉样蛋白SUVR差异较高，为0.024（p = 0.048）；尽管只有该区域达到统计学显著性，但所有区域的关联在幅度和方向上相似。WRS每恶化（下降）10%，左侧颞叶（β = 0.053，p = 0.018）、右侧颞叶（β = 0.055，p = 0.006）、左侧顶叶（β = 0.068，p = 0.006）、右侧顶叶（β = 0.076，p = 0.001）、左侧扣带回（β = 0.076，p = 0.004）、右侧扣带回（β = 0.088，p = 0.002）和右侧额叶（β = 0.052，p = 0.035）区域以及全局（β = 0.064，p = 0.005）的淀粉样蛋白SUVR差异较高。
结论： 较差的听力与淀粉样蛋白PET扫描中多个脑区较高的淀粉样蛋白相关，并且似乎是由听力损失和淀粉样蛋白负担最严重的病例所致。这些微小效应关联的原因，以及听力是否可能与淀粉样斑块存在因果关系，需要进一步研究。
英文摘要
OBJECTIVES: Investigate the association of hearing loss (HL), measured by pure-tone average (PTA) and word recognition score (WRS) in the better ear, with cerebral amyloid deposition, measured with amyloid positron emission tomography (PET).
METHODS: Two-hundred twenty-three participants were included. Primary outcomes included whole brain and regional amyloid standardized uptake value ratio (SUVR) on PET. Primary exposures were PTA and WRS. Multivariable linear regression controlling for relevant covariates was used.
RESULTS: Average participant age (SD) was 65.6 (3.8) years and average PTA was 21.0 (8.5) dB. In the fully adjusted model, there was a higher amyloid SUVR difference of 0.024 (p = 0.048) per 10 dB worsening (increase) in PTA in the left temporal region; though only this region reached statistical significance, associations were similar in magnitude and direction across all regions. For every 10% worsening (decrease) in WRS, there was a higher amyloid SUVR difference in the left temporal (β = 0.053, p = 0.018), right temporal (β = 0.055, p = 0.006), left parietal (β = 0.068, p = 0.006), right parietal (β = 0.076, p = 0.001), left cingulate (β = 0.076, p = 0.004), right cingulate (β = 0.088, 9 p = 0.002), and right frontal (β = 0.052, p = 0.035) regions and globally (β = 0.064, p = 0.005).
CONCLUSION: Worse hearing was associated with higher amyloid in several brain regions on amyloid PET scans and appeared to be due to cases with the most HL and amyloid burden. The reason for these small effect associations, and whether hearing could be causally related to amyloid plaque, requires further investigation.