耳鸣相关情绪困扰是否存在独特的脑电特征？来自频谱参数化和源水平功能连接的证据

文献信息

中文摘要

主观性耳鸣是在没有外部声源的情况下感知到声音。本研究使用静息态脑电图（EEG）来表征可能与耳鸣相关情绪困扰有关的异常神经振荡活动和电生理特征。从耳鸣患者和健康对照者中收集静息态EEG数据。应用频谱参数化来分离非周期性和周期性成分，并提取α中心频率。同时，计算源水平相位锁定值（PLV）以评估区域间功能连接。耳鸣患者表现出显著高于健康对照者的非周期性指数，这与皮层兴奋-抑制（E/I）平衡改变一致。此外，颞区的α峰值频率显著降低，表明听觉皮层网络内局部振荡活动减慢。功能连接分析显示，听觉和顶叶区域内及区域间的同步性增加，同时涉及听觉区域、前扣带皮层和前额叶区域的连接性降低。这些发现表明，耳鸣的特征是神经振荡活动和功能连接改变。这些改变可能反映耳鸣中异常的听觉网络同步和皮层动力学改变，并可能代表与耳鸣相关情绪困扰有关的电生理特征，这些特征与原发性抑郁障碍中先前报道的一些发现并不完全一致。这些结果进一步阐明了耳鸣的神经生理基础，并可能为未来的神经调控干预提供信息。

英文摘要

Subjective tinnitus is the perception of sound in the absence of an external acoustic source. This study used resting-state electroencephalography (EEG) to characterize abnormal neural oscillatory activity and electrophysiological features potentially associated with tinnitus-related emotional distress. Resting-state EEG data were collected from patients with tinnitus and healthy controls. Spectral parameterization was applied to separate aperiodic and periodic components and to extract the alpha center frequency. At the same time, source-level phase-locking value (PLV) was calculated to assess inter-regional functional connectivity. Patients with tinnitus exhibited a significantly higher aperiodic exponent than healthy controls, consistent with altered cortical excitation-inhibition (E/I) balance. In addition, the alpha peak frequency was significantly reduced in temporal regions, indicating slowing of local oscillatory activity within auditory cortical networks. Functional connectivity analysis revealed increased synchronization within and between auditory and parietal regions, accompanied by decreased connectivity involving the auditory regions, the anterior cingulate cortex, and prefrontal regions. These findings suggest that tinnitus is characterized by altered neural oscillatory activity and functional connectivity. These alterations may reflect abnormal auditory-network synchronization and altered cortical dynamics in tinnitus and may represent electrophysiological characteristics associated with tinnitus-related emotional distress that are not fully consistent with some findings previously reported in primary depressive disorders. These results further clarify the neurophysiological basis of tinnitus and may inform future neuromodulatory interventions.