富血小板浓缩物治疗颞肌筋膜鼓膜成形术对慢性中耳炎所致鼓膜穿孔的疗效：系统评价与Meta分析
Efficacy of Treatment with Platelet-Rich Concentrate on Temporalis Fascia Myringoplasty for Managing Tympanic Membrane Perforation Due to Chronic Otitis Media: A Systemic Review and Meta-analysis.
文献信息
| PMID | 42732643 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Do Hyun Kim |
| 作者单位 | Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. |
| 期刊 | The journal of international advanced otology |
| SCI 分区 | Q3 |
| IF | 1.3 |
| 研究类型 | 综述 Meta · 临床 |
| 所属专科 | 耳科 |
中文摘要
本Meta分析评估了颞肌筋膜鼓膜成形术（TFM）联合富血小板浓缩物（PRC）对慢性中耳炎（COM）所致鼓膜（TM）穿孔中鼓膜愈合的疗效，并与单纯TFM进行比较。全面检索了PubMed、SCOPUS、EMBASE、Web of Science和Cochrane Library。干预组接受TFM加PRC，对照组仅接受TFM。测量的关键结局包括成功率（鼓膜完全愈合）、术后感染发生率、气骨导差（ABG）和空气传导（AC）的变化，以及听力图中记录的术后听力改善至少10分贝的患者比例。采用标准化均数差或比值比及95%置信区间确定合并效应。共纳入24项研究（n=1669）。TFM联合PRC在ABG和AC方面带来更大改善。干预组术后听力改善显著增加，在听力图上超过10分贝，并且成功率更高。按穿孔大小进行的亚组分析显示，干预组在中等和大穿孔中取得了更优的结局。此外，PRC应用显著降低了术后感染的发生率。在TFM期间应用自体PRC可提高手术成功率和听力改善，尤其是在中等和大穿孔中，同时降低术后感染率。
英文摘要
This meta-analysis assessed the efficacy of temporalis fascia myringoplasty (TFM) combined with platelet-rich concentrate (PRC) on tympanic membrane (TM) healing in TM perforation due to chronic otitis media (COM), compared to TFM alone. A comprehensive search was conducted across PubMed, SCOPUS, EMBASE, Web of Science, and the Cochrane Library. The intervention group underwent TFM with the addition of PRC, while the control group received TFM alone. Key outcomes measured included the success rate (complete TM healing), postoperative infection incidence, changes in air-bone gap (ABG) and air conduction (AC), and the proportion of patients experiencing postoperative auditory improvement of at least 10 decibels, as recorded in audiograms. Pooled effects were determined using standardized mean differences or odds ratios, with 95% CIs. Twenty-four studies (n=1669) were included. TFM combined with PRC led to greater improvements in ABG and AC. The intervention group showed a significant increase in postoperative auditory improvement, exceeding 10 decibels in audiograms, as well as a higher success rate. Subgroup analysis by perforation size revealed that the intervention group achieved superior outcomes in medium and large perforations. Additionally, PRC application significantly reduced the incidence of postoperative infection. Autologous PRC application during TFM enhances surgical success and hearing improvement, especially in medium and large perforations, while also lowering postoperative infection rates.