三维视频眼动图对前庭电刺激反应的眼动分析

文献信息

中文摘要

背景： 传统电生理技术难以定量评估前庭神经活动。本研究旨在开发一种将前庭电刺激（GVS）与三维视频眼动图（3D-VOG）相结合的新方法，以无创方式评估前庭功能。
方法： 使用高分辨率红外VOG系统（yVOG，山口大学）记录健康个体的眼动。在双侧乳突部施加不同电流强度（0.5-2.0 mA）和极性的双极GVS。提取水平、垂直和旋转眼动成分，并分析其与刺激参数的关系。
结果： 旋转性眼震的振幅和慢相速度随刺激强度成比例增加，并随极性反转而反向。健康参与者表现出对称性反应。诱发的眼动反应显示出可重复的极性和强度依赖性特征。
结论： 本研究表明，GVS-VOG通过眼动分析提供了一种直接、可重复且无创的前庭神经功能评估方法。该方法在未来临床应用中可能补充现有的前庭功能检查。前庭电刺激-视频眼动图还可通过将生理机制与可观察的眼动反应联系起来，在研究和临床环境中发挥作用。这种方法有望成为前庭疾病的诊断工具，尤其是在传统检查结果不明确时。

英文摘要

BACKGROUND: Quantitative assessment of vestibular nerve activity has been difficult with conventional electrophysiological techniques. This study aimed to develop a novel method combining galvanic vestibular stimulation (GVS) with 3-dimensional video-oculography (3D-VOG) to evaluate vestibular function noninvasively.
METHODS: Eye movements were recorded from healthy individuals using a high-resolution infrared VOG system (yVOG, Yamaguchi University). Bipolar GVS was applied bilaterally over the mastoid processes with various current intensities (0.5-2.0 mA) and polarities. Horizontal, vertical, and torsional eye-movement components were extracted and analyzed in relation to stimulus parameters.
RESULTS: Torsional nystagmus amplitude and slow-phase velocity increased proportionally with stimulus intensity and reversed with polarity. Healthy participants exhibited symmetric responses. The induced eye-movement responses showed reproducible polarity- and intensity-dependent characteristics.
CONCLUSION: This study demonstrates that GVS-VOG provides a direct, reproducible, and noninvasive means of evaluating vestibular nerve function through eye movement analysis. The method may complement existing vestibular function tests in future clinical applications. Galvanic vestibular stimulation-video-oculography also offers utility in both research and clinical settings by linking physiological mechanisms with observable oculomotor responses. This approach holds promise as a diagnostic tool for vestibular disorders, especially when conventional tests yield inconclusive results.