心房颤动与听力损失之间的关联：一项横断面研究。
Association Between Atrial Fibrillation and Hearing Loss: A Cross-Sectional Study.
文献信息
| PMID | 42732625 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Ye Ji Shim |
| 作者单位 | Department of Otorhinolaryngology-Head and Neck Surgery, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea. |
| 期刊 | The journal of international advanced otology |
| SCI 分区 | Q3 |
| IF | 1.3 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
背景： 心房颤动（AF）通过血栓栓塞和微血管功能障碍等机制与多种终末器官并发症相关。耳蜗因其高代谢需求和有限的侧支循环，特别容易受到循环障碍的影响。然而，AF与听力损失之间的关联仍知之甚少，既往研究证据有限且存在矛盾。因此，本研究旨在探讨AF与听阈之间的关联。
方法： 对129名接受纯音测听、12导联心电图和24小时动态心电图监测的成年人进行了一项单中心横断面研究。受试者被分为AF组（n=42）和对照组（n=87）。主要结局为0.5、1、2和4 kHz的较好耳平均听阈。采用广义相加模型评估AF与听阈之间的关联，并调整年龄、性别、体重指数和其他心脏代谢危险因素。还进行了频率特异性分析。
结果： 调整协变量后，AF与听阈升高4.28 dB HL独立相关（95% CI：3.47-5.10，P=.017）。频率特异性分析显示，该关联在4 kHz处最为显著，该频率下听阈升高7.40 dB HL（95% CI：2.27-10.05，P=.004）。
结论： 本研究提供了AF与听力损失之间关联的初步证据，提示在旨在识别听力损失可改变危险因素的研究中可考虑AF。
英文摘要
BACKGROUND: Atrial fibrillation (AF) is associated with various end-organ complications through mechanisms including thromboembolism and microvascular dysfunction. The cochlea, with its high metabolic demands and limited collateral circulation, is particularly vulnerable to circulatory disturbances. However, the association between AF and hearing loss remains poorly understood, with limited and conflicting evidence from prior studies. Therefore, this study aimed to investigate the association between AF and hearing thresholds.
METHODS: A single-center, cross-sectional study was conducted on 129 adults who underwent pure-tone audiometry, 12-lead electrocardiography, and 24-hour Holter monitoring. Subjects were categorized into an AF group (n=42) and a control group (n=87). The primary outcome was the better-ear average hearing threshold across 0.5, 1, 2, and 4 kHz. Generalized additive models were used to assess the association between AF and hearing thresholds, adjusting for age, sex, body mass index, and other cardiometabolic risk factors. Frequency-specific analyses were also conducted.
RESULTS: After adjusting for covariates, AF was independently associated with a 4.28 dB HL elevation in hearing thresholds (95% CI: 3.47-5.10, P=.017). Frequency-specific analyses revealed that the association was most pronounced at 4 kHz, with a 7.40 dB HL elevation at this frequency (95% CI: 2.27-10.05, P=.004).
CONCLUSION: This study provides preliminary evidence of an association between AF and hearing loss, suggesting that AF could be considered in investigations aimed at identifying modifiable risk factors for hearing loss.