1,8-桉叶油素治疗中耳炎患者中的细菌和真菌群落及网络动态

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中文摘要

本研究探讨了慢性中耳炎患者在接受天然单萜类药物1,8-桉叶油素作为有前景的治疗方案后，其细菌和真菌群落以及跨域网络相互作用的变化。虽然细菌群落变化不大，核心菌属得以保留，但真菌群落经历了显著的多样化和网络扩展。这表明治疗可能破坏了真菌群落中的竞争排斥机制，从而增加了多样性和相互作用，尽管传统多样性指标没有显著变化。对1,8-桉叶油素治疗中耳炎患者微生物群落组成的研究发现，应答者和非应答者的初始微生物特征存在显著差异。值得注意的是，治疗应答的慢性中耳炎患者在基线时表现出显著更高丰度的不同革兰阴性假单胞菌属。相比之下，与非应答组相比，1,8-桉叶油素应答患者中观察到多种革兰阳性棒状杆菌属水平显著升高。这些关键分类群可能代表治疗干预的新靶点或治疗应答的生物标志物。

英文摘要

The present study investigated the bacterial and fungal communities and cross-domain network interactions in patients with chronic Otitis media in response to the natural monoterpene medicinal 1,8-Cineol as a promising treatment option. While the bacterial community showed modest changes with preserved core genera, the fungal community underwent dramatic diversification and network expansion. This suggests that treatment may have disrupted competitive exclusion mechanisms in the latter, allowing for increased diversity and interactions, despite no significant changes in traditional diversity metrics. Investigations on the microbial community compositions in Otitis media patients upon 1,8-Cineol treatment revealed significantly different initial microbial signatures in responders and non-responders. Notably, therapy-responding COM patients demonstrated a baseline situation with significantly higher abundances of different gram-negative Pseudomonas species. In contrast, significantly elevated levels of various gram-positive Corynebacterium species were observed in the non-responder group compared to the 1,8-Cineol responding patients. These keystone taxa may represent new targets for therapeutic intervention or biomarkers for treatment response.