衰老、听神经健康及加工速度对人工耳蜗使用者心理物理间隙检测阈值的贡献
Contributions of aging, auditory nerve health, and speed of processing to psychophysical gap detection thresholds in cochlear implant users.
文献信息
| PMID | 42731434 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Kara C Schvartz-Leyzac |
| 作者单位 | Medical University of South Carolina, Department of Otolaryngology-Head & Neck Surgery, 135 Rutledge Ave, MSC 550, Charleston, SC, 29425, USA. Electronic address: leyzac@musc.edu. |
| 期刊 | Hearing research |
| SCI 分区 | Q1 |
| IF | 3.2 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
对时间性言语线索的精确编码对于言语理解至关重要，对接受有限频谱信息的人工耳蜗（CI）使用者尤为重要。静音间隙检测是听觉时间精度的一个简单指标，但驱动CI间隙检测阈值（GDTs）变异的机制和刺激参数仍不清楚。本研究的总体目的是描述听神经（AN）密度、衰老、脉冲速率和认知加工速度如何影响成人CI使用者的GDTs。二十名语后聋成人Cochlear™ CI使用者（37-87岁）参与了研究。我们使用直接刺激技术记录了电诱发复合动作电位（ECAPs）和心理物理间隙检测。ECAP相间间隙（IPG）斜率效应被用作AN密度的估计。GDTs使用500和3500 pps脉冲串在每耳两个电极上测量，配对最高和最低IPG效应。认知加工速度用Connections Test评估。CNC单词识别在声场中测量。GDTs随年龄增加而增加（变差）；但使用较高脉冲速率时总体降低（改善），且年轻CI使用者比年长CI使用者改善更多。AN密度估计并未预测GDTs。当使用较高而非较低脉冲速率时，较慢的认知加工速度与较差的GDTs相关。这些结果表明，在较高脉冲速率下，中枢/认知机制而非AN密度状态可预测成人CI使用者对时间间隙的编码，尤其是在使用较高脉冲速率刺激时。
英文摘要
Precise encoding of temporal speech cues is critical for speech understanding and are especially important for cochlear implant (CI) users, who receive limited spectral information. Silent gap detection is a simple index of auditory temporal precision, yet mechanisms and stimulus parameters driving variability in CI gap detection thresholds (GDTs) remain unclear. The overall aim of this study was to describe how AN density, aging, pulse rate, and cognitive speed of processing contribute to GDTs in adult CI users. Twenty post-lingually deafened adult Cochlear™ CI users (37-87 years) participated. We recorded electrically evoked compound action potentials (ECAPs) and psychophysical gap detection using direct stimulation techniques. ECAP interphase gap (IPG) slope effect was used as an estimate of AN density. GDTs were measured with 500 and 3500 pps pulse trains on two electrodes per ear paired with the highest and lowest IPG effect. Cognitive processing speed was assessed with the Connections Test. CNC word recognition was measured in the sound field. GDTs increased (worsened) with increasing age; but decreased (improved) overall when using a higher compared to lower pulse rate but more so for younger compared to older CI users. Estimates of AN density did not predict GDTs. Slower cognitive processing speed was associated with poorer GDTs, when using higher but not lower pulse rates. These results suggest that, at higher pulse rates central/cognitive mechanisms but not AN density status, predict encoding of temporal gaps in adult CI users particularly when using higher pulse rate stimuli.