女性喉癌患者的治疗结果
Laryngeal Carcinoma Treatment Outcomes in Female Patients.
文献信息
| PMID | 42731012 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Carly A Clark |
| 作者单位 | Department of Otolaryngology, University of Kentucky, Lexington, Kentucky, USA. |
| 期刊 | The Laryngoscope |
| SCI 分区 | Q2 |
| IF | 2.3 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
目的： 本研究旨在描述女性喉癌患者的特征，并比较手术治疗与非手术治疗。
方法： 开展了一项回顾性队列研究，作为多中心研究，收集了2003年至2020年在肯塔基大学以及2001年至2021年在阿拉巴马大学伯明翰分校诊断为喉癌的所有女性患者的数据。采用连续抽样方法，共确定255例诊断为喉癌的患者。排除无诊断日期、病理结果和治疗状态的参与者。计划的研究结局是评估术前特征、表现、治疗和结局。我们还比较了接受手术治疗与接受非手术治疗患者的治疗结局。
结果： 共纳入255例患者，诊断时的中位年龄为59.5岁。分别有93.7%和26.6%的患者报告吸烟和饮酒。最常见的喉癌亚部位为声门上型（n=160，62.7%）。在记录了分期和主要治疗的患者中（n=244），64.3%表现为T3或T4期疾病。共有75例患者记录到复发/持续存在，其中68%的复发患者报告挽救性手术为次要治疗。对于所有患者，发现手术治疗相比非手术主要治疗可改善结局。
结论： 随着女性患者中喉癌发病率的增加，在推荐治疗时应考虑女性患者特有的特征。基于这些数据，希望进一步分析女性患者，并检查可能影响未来治疗指南的性别差异。
英文摘要
OBJECTIVE: This study aims to describe characteristics of female patients with laryngeal cancer and to compare surgical and non-surgical treatment.
METHODS: A retrospective cohort study was performed as a multicenter study with data collected from all female patients diagnosed with larynx cancer at University of Kentucky from 2003 to 2020 and at University of Alabama at Birmingham from 2001 to 2021. Consecutive sampling was used to identify a total of 255 patients diagnosed with laryngeal cancer. Participants without date of diagnosis, pathology results, and treatment status were excluded. The planned study outcome was to evaluate preoperative characteristics, presentation, treatment, and outcomes. We also examined treatment outcomes for patients treated with surgical compared to non-surgical options.
RESULTS: The 255 patients were included, with a median age of diagnosis of 59.5. Tobacco use and alcohol use were reported in 93.7% and 26.6% of patients, respectively. The most common laryngeal cancer subsite was supraglottic (n = 160, 62.7%). Of the patients with staging and primary treatment recorded (n = 244), 64.3% presented with T3 or T4 disease. Recurrence/persistence was documented in a total of 75 patients, with salvage surgery reported as secondary treatment in 68% of patients with recurrence. For all patients, surgical therapy was found to have improved outcomes over non-surgical primary therapy.
CONCLUSION: With an increasing incidence of laryngeal cancer in female patients, characteristics unique to female patients should be considered when recommending therapy. With this data, the hope is to further analyze female patients and examine sex-based differences that may influence future treatment guidelines.