MFR、SVR和ASVR作为超重和肥胖人群阻塞性睡眠呼吸暂停综合征中有前景的生物标志物：一项观察性研究的见解。
MFR, SVR and ASVR as promising biomarkers in overweight and obese population with obstructive sleep apnea syndrome: insights from an observational study.
文献信息
| PMID | 42730720 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Hongbin Zhou |
| 作者单位 | Geriatric Medicine Center, Department of Pulmonary and Critical Care Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, China. |
| 期刊 | Annals of medicine |
| SCI 分区 | Q1 |
| IF | 5.2 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 肥胖是阻塞性睡眠呼吸暂停综合征（OSAS）的重要危险因素，但并非所有肥胖者都会发展为OSAS。新型人体成分指标——肌肉与脂肪比率（MFR）、骨骼肌质量与内脏脂肪面积比率（SVR）以及四肢骨骼肌质量与内脏脂肪面积比率（ASVR）——在OSAS中的作用在很大程度上仍不清楚。本研究旨在探讨这些指标与超重和肥胖成人OSAS的关联。
方法： 本研究纳入具有完整人体成分和多导睡眠监测数据的超重或肥胖患者。回顾性收集体格检查、Epworth嗜睡量表及人口学信息数据。受试者被分为两组，分别命名为非OSAS组和OSAS组。比较两组间的MFR、SVR和ASVR。进行逻辑回归分析、限制性立方样条分析和中介分析，以评估这些指标与OSAS之间的关系。此外，绘制受试者工作特征（ROC）曲线以评估这些指标在OSAS诊断中的价值。
结果： 本研究共纳入192例超重或肥胖患者，其中包括122例OSAS患者。与非OSAS患者相比，OSAS患者年龄更大，男性、吸烟史比例更高，且合并症更多。OSAS组的MFR、SVR和ASVR更高，尤其是在男性OSAS患者中。然而，这些指标并非OSAS的独立危险因素。中介分析表明，这些指标可能中介年龄与OSAS之间的关系，但这种效应受性别影响。ROC曲线显示，这些指标在症状较少的受试者中诊断OSAS具有较高的敏感性和特异性。
结论： 在超重和肥胖成人中，男性OSAS患者的MFR、SVR和ASVR升高。这些指标可能有助于早期识别症状较少的OSAS患者，尤其是在初级保健环境中。
英文摘要
BACKGROUND: Obesity is an important risk factor of obstructive sleep apnea syndrome (OSAS), but not all obese people can develop OSAS. The role of novel human body composition indices-muscle-to-fat ratio (MFR), skeletal muscle mass-to-visceral fat area ratio (SVR) and appendicular skeletal muscle mass-to-visceral fat area ratio (ASVR)-in OSAS remains largely unknown. The aim of this study is to investigate the associations of these indices to OSAS in overweight and obese adults.
METHODS: Overweight or obese patients with complete human body composition and polysomnography data were included in this study. The data of physical examination, Epworth sleepiness scale and demographic information were retrospectively collected. Subjects were divided into two groups, named non-OSAS and OSAS. MFR, SVR and ASVR were compared between two groups. Logistic regression analysis, restricted cubic spline analysis and mediation analysis were conducted to evaluate the relationship between these indices and OSAS. Moreover, receiver operating characteristic (ROC) curves were drawn to evaluate these indices in OSAS diagnosis.
RESULTS: A total of 192 overweight or obese patients were enrolled in this study, including 122 OSAS patients. Compared with non-OSAS patients, OSAS patients were older and exhibited higher frequency of male, smoking history and more comorbidities. MFR, SVR and ASVR were higher in OSAS group, especially in male OSAS patients. However, these indices were not independent risk factors to OSAS. Mediation analysis presented these indices might mediate the relationship between age and OSAS, but this effect was affected by sex. ROC curves showed these indices had high sensitivity and specificity in OSAS diagnosis in subjects with less symptoms.
CONCLUSION: MFR, SVR and ASVR increased in male OSAS patients in overweight and obese adults. These indices might contribute to early recognizing OSAS patients with less symptoms, especially in primary care settings.