Article record

支气管肺发育不良婴幼儿的耳科结局

Otologic outcomes in infants and children with bronchopulmonary dysplasia.

临床研究耳科IF 1.7Q2

文献信息

PMID	42721665
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Natalie Quinn 查看其他 14 位作者 Olivia Chan；Holly Gerth；Angie Zemba；Zheng Hong Tan；Melissa Bees；Kelly Giroux；Alexandra Gach；Aidan Vanek；Win Adissem；Megan McNutt；Matthew J Kielt；Isaac Kistler；Tendy Chiang；Ursula Findlen
作者单位	The Ohio State University College of Medicine, Columbus, OH, USA. 查看其他 6 条单位信息 Department of Audiology, Nationwide Children's Hospital, Columbus, OH, USA.；Department of Pediatric Otolaryngology, Nationwide Children's Hospital, Columbus, OH, USA.；The University of Toledo College of Medicine, Toledo, OH, USA.；Department of Neonatology, Nationwide Children's Hospital, Columbus, OH, USA.；Center for Biostatistics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA; Biostatistics Resource, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, 43205, USA.；Department of Audiology, Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatric Otolaryngology, Nationwide Children's Hospital, Columbus, OH, USA. Electronic address: ursula.findlen@nationwidechildrens.org.
期刊	International journal of pediatric otorhinolaryngology
SCI 分区	Q2
IF	1.7
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

目的： 支气管肺发育不良（BPD）患儿的听力结局尚未在不同疾病严重程度间得到充分描述，且社区层面机会对耳科结局的影响仍不明确。我们旨在确定按疾病严重程度分层的BPD患儿中听力损失（HL）、中耳病变和手术管理的患病率，并评估儿童机会指数（COI）对耳科相关差异的贡献。
方法： 我们开展了一项单机构、回顾性队列研究，纳入0-8岁、入住三级新生儿重症监护病房并诊断为BPD的儿童。患者按BPD严重程度（Jensen标准）分组。结局包括新生儿听力筛查（NBHS）结果、诊断性听力学评估（DE）、中耳病变史以及鼓膜置管时间。模型对胎龄和出生体重进行了校正。
结果： 在1077份记录中，纳入924份。NBHS结果因BPD严重程度而异（p < 0.001），在完成DE的患者中，BPD越严重者发生永久性HL的风险越高（p < 0.001）。传导性HL、中耳病变和手术管理的患病率在各分级间无显著差异。57%的队列接受了推荐的DE。低COI与完成DE的几率较低独立相关。
结论： BPD越严重的婴儿发生NBHS未通过和永久性HL的风险越高，应接受密切监测以进行评估和治疗。来自低机会社区的BPD儿童可能面临DE和耳科护理可及性降低的问题，凸显了采取公平护理策略的必要性。
证据等级： III。

英文摘要

OBJECTIVE: Hearing outcomes among children with bronchopulmonary dysplasia (BPD) have not been well characterized across disease severity, and the impact of neighborhood-level opportunity on otologic outcomes remains unclear. We aimed to determine the prevalence of hearing loss (HL), middle ear pathology, and surgical management among children with BPD stratified by disease severity, and to evaluate the contribution of the Childhood Opportunity Index (COI) to otologic-related disparities.
METHODS: We performed a single-institution, retrospective cohort study of children aged 0-8 years admitted to a tertiary care neonatal intensive care unit and diagnosed with BPD. Patients were grouped by BPD severity (Jensen criteria). Outcomes included newborn hearing screening (NBHS) results, diagnostic audiology evaluation (DE), history of middle ear pathology, and time to tympanostomy tube placement. Models were adjusted for gestational age and birthweight.
RESULTS: Of 1077 records, 924 were included. NBHS outcomes varied by BPD severity (p < 0.001), and among patients with completed DE, those with more severe BPD had a higher risk of permanent HL (p < 0.001). The prevalence of conductive HL, middle ear pathology, and surgical management did not differ significantly between grades. 57% of the cohort received the recommended DE. Low COI was independently associated with lower odds of completing DE.
CONCLUSION: Infants with greater BPD severity have a higher risk of non-pass NBHS and permanent HL and should undergo close monitoring for evaluation and treatment. Children with BPD from low-opportunity neighborhoods may experience reduced access to DE and otologic care, highlighting the need for equitable care strategies.
LEVEL OF EVIDENCE: III.