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[18F]NaF和[18F]FDG PET/CT在评估甲状软骨分子钙化和葡萄糖代谢中的应用

Application of [18F]NaF and [18F]FDG PET/CT to Assess Molecular Calcification and Glucose Metabolism in Thyroid Cartilage.

临床研究咽喉科IF 3.4Q2

文献信息

PMID42721223
原文在 PubMed 查看原文 ↗
发表日期2026
作者Niloofaralsadat Motamedi
查看其他 10 位作者

Shashi Bhushan Singh；Miraziz Ismoilov；Saira K Niazi；Bimash B Shrestha；Malia Ahmed；Om H Gandhi；Thomas J Werner；Drew A Torigian；Abass Alavi；Mona-Elisabeth Revheim

作者单位Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
查看其他 5 条单位信息

Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA.；Department of Nuclear Medicine, The University of Oklahoma Health Sciences, Oklahoma, OK, USA.；Department of Cardiology, Lewis Katz School of Medicine-Temple Heart and Vascular Institute, 3500 N Broad St, Philadelphia, PA, USA.；The Intervention Center, Division for Technology and Innovation, Oslo University Hospital, Oslo, Norway.；Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

期刊Cartilage
SCI 分区Q2
IF3.4
研究类型临床研究 · 临床
所属专科咽喉科

中文摘要

目的： 甲状软骨钙化和葡萄糖代谢可能随年龄和性别而变化。本研究探讨了[18F]-氟化钠（[18F]NaF）和2-[18F]氟-2-脱氧-D-葡萄糖（[18F]FDG）PET/CT在评估甲状软骨随年龄变化的生理性分子钙化和葡萄糖代谢中的作用。方法：这项回顾性研究分析了来自CAMONA研究（NCT01724749）的[18F]NaF和[18F]FDG PET/CT图像。使用OsiriX软件在CT图像上围绕甲状软骨放置感兴趣区。测量[18F]NaF和[18F]FDG PET/CT图像的平均标准化摄取值（SUVmean）。计算Pearson相关系数以评估衰老对甲状软骨中[18F]NaF和[18F]FDG的影响。结果：共纳入127名健康受试者（65名女性和62名男性），平均年龄48.46 ± 14.13岁（范围21-75岁）进行[18F]NaF PET/CT，以及114名健康受试者（52名女性和62名男性），平均年龄49.05 ± 14.29岁（范围22-75岁）进行[18F]FDG PET/CT。观察到年龄与甲状软骨中[18F]NaF的SUVmean呈显著正相关（r = 0.18，p = 0.04），表明该软骨的分子钙化随衰老而增加。然而，年龄与甲状软骨中[18F]FDG的SUVmean之间的相关性无统计学意义（r = -0.09，p = 0.31）。结论：本研究提出了一种使用[18F]NaF和[18F]FDG PET/CT测定喉软骨分子钙化和葡萄糖代谢的新方法。甲状软骨的分子钙化随年龄增加，而葡萄糖代谢与年龄无统计学显著相关性。

英文摘要

ObjectiveThyroid cartilage calcification and glucose metabolism may vary with age and gender. This study investigated the role of [18F]-sodium fluoride ([18F]NaF) and 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) PET/CT in evaluating of physiological molecular calcification and glucose metabolism of thyroid cartilage with age.MethodsThis retrospective study analyzed [18F]NaF and [18F]FDG PET/CT images from the CAMONA study (NCT01724749). Regions of interest were placed around the thyroid cartilage on CT images using OsiriX software. The mean standardized uptake value (SUVmean) was measured for [18F]NaF and [18F]FDG PET/CT images. Pearson correlation coefficients were calculated to evaluate the effects of aging on [18F]NaF and [18F]FDG in the thyroid cartilage.ResultsA total of 127 healthy subjects (65 females and 62 males) with a mean age of 48.46 ± 14.13 (range 21-75) years for [18F]NaF PET/CT and 114 healthy subjects (52 females and 62 males) with a mean age of 49.05 ± 14.29 (range 22-75) years for [18F]FDG PET/CT were included. A significant positive correlation was observed between age and SUVmean of [18F]NaF in the thyroid cartilage (r = 0.18, p = 0.04), indicating that molecular calcification of this cartilage increases with aging. However, the correlation between age and SUVmean of [18F]FDG in the thyroid cartilage was not statistically significant (r = -0.09, p = 0.31).ConclusionThis study presents a novel methodology for the determination of molecular calcification and glucose metabolism of laryngeal cartilage using [18F]NaF and [18F]FDG PET/CT. Molecular calcification of thyroid cartilage increase with age, whereas glucose metabolism did not show a statistically significant correlation with age.