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一种具有可调纵向刚度的合成各向异性声带模型

A synthetic anisotropic vocal fold model with tunable longitudinal stiffness.

基础研究咽喉科IF 2.6Q1

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中文摘要

本研究介绍了一种合成声带模型,该模型能够再现人声带的生物力学特性,特别是其以显著的纵向-横向刚度对比为特征的各向异性力学行为,同时还能在制造后进行调节。传统模型通常是各向同性的,或者需要复杂的多层构造,限制了可重复性。为解决这一问题,我们开发了一种嵌有乳胶管的室温硫化硅胶模型。该模型利用内部空气-水的体积比作为调节刚度的机制。增加水比例会增加纵向刚度,而横向特性保持不变,且宏观上不改变几何形状。有限元模拟和单轴压缩测试证实了这种行为,显示纵向杨氏模量显著增加了12.5倍(从15.7 kPa升至196 kPa),而横向刚度仍接近硅胶的刚度。使用调制气流和恒定气流的动态测试表明,振动模式与生理性发声一致。基频随刚度增加而增加,相对于空管(0%水)基线,在50%和100%水比例下,基频分别比原始基频共振高出2%和8%。与其对应构造相比,该模型具有简单性,最重要的是制造后可调节性。这些优势使其成为发声研究、病理建模和设备测试的有前景的工具。

英文摘要

This study introduces a synthetic vocal fold model that captures the biomechanical properties of human vocal folds, specifically their anisotropic mechanical behavior characterized by a pronounced longitudinal-transverse stiffness contrast, while also enabling post-fabrication tunability. Conventional models are often isotropic or necessitate complex multilayer construction, limiting reproducibility. To address this, we developed a room temperature vulcanized silicone model with an embedded latex tube. This model employs the internal air-water volumetric ratio as a mechanism to modulate stiffness. Increasing the water ratio increases longitudinal stiffness while leaving transverse properties unchanged without macroscopically altering geometry. Finite element simulations and uniaxial compression tests confirmed this behavior, demonstrating a remarkable 12.5-fold increase in longitudinal Young's modulus (rising from 15.7  to 196 kPa), whereas transverse stiffness remained close to that of the silicone. Dynamic testing with modulated and constant airflow demonstrated vibrational patterns consistent with physiological phonation. Fundamental frequencies increased with stiffness, reaching 2% and 8% above the original fundamental resonance at 50%, and 100% water ratios, relative to the empty-tube (0% water) baseline. Compared to its counterpart constructs, this model offers simplicity and most importantly post-manufacture tunability. These advantages make it a promising tool for research in phonation, pathological modeling, and device testing.