视网膜静脉阻塞患者中睡眠呼吸暂停的高发病率
High Incidence of Sleep Apnea in Patients with Retinal Vein Occlusions.
文献信息
| PMID | 42720980 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Patrick Higgins |
| 作者单位 | Orlando College of Osteopathic Medicine, Winter Garden, Florida. |
| 期刊 | Retina (Philadelphia, Pa.) |
| SCI 分区 | Q3 |
| IF | 2.5 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 在我们新诊断视网膜静脉阻塞（RVO）的前瞻性队列中，使用多导睡眠监测（PSG）确定既往未诊断的阻塞性睡眠呼吸暂停（OSA）患者的患病率，并与我们既往已诊断的RVO受试者回顾性对照组中根据既往病史（PMH）确定的OSA发生率进行比较。
方法： 这项单中心回顾性和前瞻性队列研究纳入了2016年1月至2025年10月期间在新泽西视网膜中心就诊的321例分支型（BRVO）、半中央型（HCRVO）或中央型视网膜静脉阻塞（CRVO）患者。将272例患者的回顾性队列与49例新诊断RVO患者的前瞻性队列进行比较，后者接受了家庭或实验室PSG检测。记录了人口统计学资料、BMI和全身合并症。排除了标准化OSA筛查问卷，以纳入所有患者，而不论其主观筛查评估结果如何。主要结局为PSG确诊的OSA患病率以及与基于PMH的OSA患病率的比较。
结果： 在272例回顾性RVO患者中，14例（5.15%）报告既往诊断为OSA。在前瞻性队列中，49例患者中有4例（8.16%）报告患有重度OSA。排除这些患者后，PSG在45例患者中的38例（84.44%）发现了未诊断的OSA。PSG在49例患者中的42例（85.71%）发现了OSA，其中包括27例（55.10%）中度至重度OSA。接受PSG的患者被诊断为OSA的可能性显著高于仅依据PMH诊断者（85.71% vs 8.16%；风险比16.65，P<0.001）。
结论： 新诊断RVO的患者中既往未诊断的OSA患病率很高，提示RVO可能是一个重要的临床指标，值得进行常规PSG评估。
英文摘要
PURPOSE: To determine the prevalence of obstructive sleep apnea (OSA) using polysomnography (PSG) in previously undiagnosed OSA patients in our prospective cohort with newly diagnosed retinal vein occlusion (RVO) and compare the incidence of OSA identified in our previously diagnosed retrospective control group of RVO subjects by past medical history (PMH).
METHODS: This single-center retrospective and prospective cohort study included 321 patients with branch (BRVO), hemi-central (HCRVO), or central retinal vein occlusion (CRVO) at Retina Center of New Jersey between January 2016 and October 2025. A retrospective cohort of 272 patients was compared with a prospective cohort of 49 newly diagnosed RVO patients who underwent home or laboratory-based PSG testing. Demographics, BMI, and systemic comorbidities were recorded. Standardized OSA screening questionnaires were excluded to include all patients regardless of subjective screening assessments. Primary outcomes were PSG-confirmed OSA prevalence and comparison with PMH-based OSA prevalence.
RESULTS: Among 272 retrospective RVO patients, 14 (5.15%) reported a prior diagnosis of OSA. In the prospective cohort, 4 of 49 patients (8.16%) reported severe OSA. Excluding these patients, PSG identified undiagnosed OSA in 38 of 45 patients (84.44%). PSG identified OSA in 42 of 49 patients (85.71%), including moderate-to-severe OSA in 27 patients (55.10%). Patients undergoing PSG were significantly more likely to be diagnosed with OSA than by PMH alone (85.71% vs 8.16%; risk ratio 16.65, P<0.001).
CONCLUSIONS: Patients with newly diagnosed RVO demonstrate a high prevalence of previously undiagnosed OSA, suggesting RVO may serve as an important clinical indicator warranting routine PSG evaluation.