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慢性前庭功能减退成人在身体、功能、生理和情绪特征方面的性别相关差异:一项横断面EXERVEST研究

Sex-related differences in the physical, functional, physiological, and emotional profile of adults with chronic vestibular hypofunction: a cross-sectional EXERVEST study.

临床研究耳科IF 2.6Q1

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中文摘要

背景: 慢性前庭功能减退(CVH)通常由疾病或损伤引起,与久坐行为、睡眠不佳和合并症相关。这项横断面描述性研究描述了CVH成人的身体、功能、生理和情绪特征,并探讨了该人群中的性别相关差异。
方法: 对患有CVH的参与者(N = 67,58岁,43名女性)进行了评估,包括身体成分、心肺适能(CRF)、平衡与跌倒风险(姿势描记法和改良动态步态指数,MDGI)、健康相关生活质量(眩晕障碍量表,DHI)、情绪特征(贝克抑郁量表[BDI-II]和贝克焦虑量表[BAI])、身体活动(PA)水平、久坐行为和睡眠质量(加速度计)。
结果: 作为一个群体,参与者的腰臀比为0.8(0.7-0.9),MDGI平均得分为61.0分,姿势描记法显示标准躯体感觉和视觉数据,DHI、BDI-II和BAI的中位数分别为26.0(16.0-34.0)、11.0(4.0-17.5)和12(7.8-20.3);睡眠效率>85%,相对于PA水平久坐行为更多(约54%),总睡眠时间(TST)减少,夜间觉醒频率高于推荐值(35.7 ± 14.7分钟)。观察到性别相关差异(P < 0.05):与男性相比,女性年龄更大,脂肪量更高(+18%),睡眠效率更好(+2.4%),就寝时间更多(+5.7%),TST更长(+8.0%),但去脂体重更低(-9.7%),视觉依赖更低(-18%),CRF更低(-20.7%)。在眩晕障碍、焦虑、抑郁或PA水平方面未观察到性别差异。
结论: CVH成人表现出多维临床特征,在若干身体、功能和生理结局方面存在性别相关差异。这些发现支持全面的临床评估,并需要进行纵向研究以确定这些差异对个性化方案的临床相关性。

英文摘要

BACKGROUND: Chronic vestibular hypofunction (CVH), often resulting from illness or injury, is linked to sedentary behaviour, poor sleep, and comorbidities. This cross-sectional descriptive study characterized the physical, functional, physiological, and emotional profiles of adults with CVH and explored sex-related differences within this population.
METHODS: Participants (N = 67, 58 yrs, 43 women) with CVH were assessed on their body composition, cardiorespiratory fitness (CRF), balance and fall risk (posturography and Modified Dynamic Gait Index, MDGI), health-related quality of life (Dizziness Handicap Inventory, DHI), emotional profile (Beck Depression Inventory [BDI-II] and Beck Anxiety Inventory [BAI]), level of physical activity (PA), sedentary behaviour, and sleep quality (accelerometry).
RESULTS: As a group, participants showed a waist-to-hip ratio of 0.8 (0.7-0.9), mean MDGI score of 61.0 points, standard somatosensory and visual data from posturography, a median values of DHI, BDI-II, and BAI of 26.0 (16.0-34.0), 11.0 (4.0-17.5), and 12 (7.8-20.3), respectively; sleep efficiency >85%, greater sedentary behaviour (∼54%) relative to PA levels, reduced total sleep time (TST) and a higher frequency of nocturnal awakenings than recommended (35.7 ± 14.7 min). Sex-related differences were observed (P < 0.05): women were older, showed higher fat mass (+18%), better sleep efficiency (+2.4%), more bedtime (+5.7%), and TST (+8.0%), but lower fat-free mass (-9.7%), visual dependence (-18%), and CRF (-20.7%) compared to men. No sex differences were observed in dizziness handicap, anxiety, depression, or PA levels.
CONCLUSIONS: Adults with CVH exhibited a multidimensional clinical profile with sex-related differences in several physical, functional, and physiological outcomes. These findings support comprehensive clinical assessment and warrant longitudinal studies to determine the clinical relevance of these differences for personalized programs.