过敏性疾病与身材矮小之间的因果关联：一项揭示炎症蛋白潜在中介作用的孟德尔随机化研究
Causal association between allergic diseases and short stature: a mendelian randomization study revealing the potential mediating role of inflammatory proteins.
文献信息
| PMID | 42716483 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Wei Yin |
| 作者单位 | Department of Pediatrics, Linping Branch, the Second Affiliated Hospital of Zhejiang University, Linping District, Hangzhou City, Zhejiang Province, China. Electronic address: yinwei1981119@163.com. |
| 期刊 | Jornal de pediatria |
| SCI 分区 | Q1 |
| IF | 3.2 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
目的： 尽管观察性研究已证实过敏性疾病与身材矮小（SS）之间存在相关性，但其因果关系尚未确立。此外，炎症蛋白与这两种疾病均密切相关；其潜在的中介作用尚未阐明。本研究旨在探讨过敏性疾病与SS之间的因果联系以及炎症蛋白的中介作用。
方法： 采用两样本孟德尔随机化（MR）分析，探讨五种过敏性疾病（过敏性鼻炎、儿童哮喘、过敏性结膜炎、特应性皮炎（AD）和荨麻疹）与SS之间的因果联系。进一步采用两步MR方法研究炎症蛋白的中介作用。
结果： 在五种过敏性疾病中，MR分析仅发现AD与SS风险之间存在提示性正相关（OR = 1.720，95%CI：1.081-2.735，P = 0.022）。同时还发现AD与炎症蛋白AXIN1水平之间存在提示性负相关（OR = 0.922，95%CI：0.855-0.995，P = 0.037）。中介分析显示，AXIN1水平可能介导了AD与SS风险之间因果通路的13.5%。
结论： 揭示了AD与SS之间潜在的正向因果联系，突出了炎症蛋白AXIN1的潜在中介作用。这些发现为旨在改善过敏性疾病患者身高生长结局的干预措施提供了科学依据和新的潜在靶点。
英文摘要
OBJECTIVE: Although observational studies have proven a correlation between allergic diseases and short stature (SS), the causal relationship remains unestablished. Furthermore, inflammatory proteins are closely linked with both conditions; their potential mediating role has yet to be elucidated. This study aimed to probe into the causal linkage between allergic diseases and SS and the mediating role of inflammatory proteins.
METHODS: A two-sample MR analysis was employed to explore the causal links between five allergic diseases (allergic rhinitis, childhood asthma, allergic conjunctivitis, atopic dermatitis (AD), and urticaria) and SS. A two-step MR approach was further used to investigate the mediating role of inflammatory proteins.
RESULTS: Among the five allergic diseases, MR analysis only identified a suggestive positive correlation between AD and the risk of SS (OR = 1.720, 95%CI: 1.081-2.735, P = 0.022). A suggestive negative association was also found between AD and the level of the inflammatory protein AXIN1 (OR = 0.922, 95%CI: 0.855-0.995, P = 0.037). Mediation analysis revealed that AXIN1 levels potentially mediated 13.5% of the causal pathway between AD and SS risk.
CONCLUSION: A potential positive causal link between AD and SS was revealed, highlighting the potential mediating role of the inflammatory protein AXIN1. These findings provide a scientific basis and a novel potential target for interventions aimed at improving height growth outcomes in patients with allergic diseases.