听觉纹状体在感觉门控与知觉决策中的作用

文献信息

中文摘要

听觉纹状体是基底神经节中与感觉相关的尾侧区域，已成为连接听觉加工与行为反应的重要节点。它整合由丘脑和皮层通路传递的自下而上的听觉信息，而自上而下的皮层信号和神经调质性多巴胺输入动态塑造这种整合，使听觉纹状体成为感觉加工与行动之间的灵活界面。近期环路水平的研究提示，该区域通过整合感觉证据和局部抑制机制，参与听觉信息过滤、时间加工和听觉引导的决策。这些发现为理解听觉信号如何转化为可指导行为的决策相关表征提供了环路框架。越来越多的证据进一步提示，这些权重和选择过程的破坏可能促成耳鸣等听觉障碍。因此，听觉纹状体可能代表一个重要的环路组分，连接听觉加工、认知与神经调质控制以及适应不良的听觉行为。

英文摘要

The auditory striatum, a caudal sensory-related region of the basal ganglia, has emerged as an important node linking auditory processing to behavioral responses. It integrates bottom-up auditory information conveyed by thalamic and cortical pathways, while top-down cortical signals and neuromodulatory dopamine inputs dynamically shape this integration, positioning the auditory striatum as a flexible interface between sensory processing and action. Recent circuit-level studies suggest that this region contributes to auditory information filtering, temporal processing, and auditory-guided decision-making through the integration of sensory evidence and local inhibitory mechanisms. These findings provide a circuit framework for understanding how auditory signals are transformed into decision-related representations that can guide behavior. Increasing evidence further suggests that disruption of these weighting and selection processes may contribute to auditory disorders such as tinnitus. Thus, the auditory striatum may represent an important circuit component linking auditory processing, cognitive and neuromodulatory control, and maladaptive auditory behavior.