慢性耳鸣中动态和静态自发活动改变及神经递质耦合
Dynamic and static spontaneous activity alterations and neurotransmitter coupling in chronic tinnitus.
文献信息
| PMID | 42716315 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Jiapei Xie |
| 作者单位 | Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China. Electronic address: 1454314461@qq.com. |
| 期刊 | Brain research bulletin |
| SCI 分区 | Q2 |
| IF | 4.2 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 本研究结合低频涨落振幅的静态和动态指标（sALFF和dALFF），探讨慢性耳鸣患者局部自发脑活动的异常及其与多种神经递质空间分布的关系，从而为理解慢性耳鸣的神经机制提供理论依据。
方法： 本研究纳入80例慢性耳鸣患者和68名健康对照。利用静息态功能磁共振成像（rs-fMRI）数据计算两组受试者的sALFF和dALFF指标，并比较组间差异。此外，分析慢性耳鸣患者ALFF改变与神经递质分布之间的关系。
结果： 与健康对照组相比，慢性耳鸣患者左侧颞上回的sALFF值显著升高，右侧楔前叶的dALFF值显著降低（GRF校正，体素水平P < 0.001，簇水平P < 0.05）。此外，sALFF的改变与5-羟色胺转运体、多巴胺、谷氨酸系统及GABA能系统的空间分布相关，dALFF的改变与5-羟色胺转运体、多巴胺能及囊泡乙酰胆碱转运体（VAChT）的空间分布相关。
结论： 慢性耳鸣不仅表现出sALFF异常，还存在动态时间涨落异常，这些异常在空间上与不同神经递质系统的分布模式相关，从而加深了对慢性耳鸣神经机制的理解。
英文摘要
OBJECTIVE: This study combined static and dynamic amplitude of low-frequency fluctuation (sALFF and dALFF) to investigate the abnormalities of local spontaneous brain activity in patients with chronic tinnitus and their relationships with the spatial distributions of multiple neurotransmitters, thereby providing a theoretical basis for understanding the neural mechanisms underlying chronic tinnitus.
METHODS: This study included 80 patients with chronic tinnitus and 68 healthy controls. Resting-state functional magnetic resonance imaging (rs-fMRI) data were used to calculate sALFF and dALFF metrics in both groups, and between-group differences were subsequently compared. Furthermore, the relationships between ALFF alterations and neurotransmitter distributions in patients with chronic tinnitus were analyzed.
RESULTS: Compared with the healthy control group, the sALFF value in the left superior temporal gyrus of patients with chronic tinnitus was significantly increased, and the dALFF value in the right precuneus was significantly decreased (GRF correction, voxel level P < 0.001, cluster level P < 0.05). Moreover, the alterations of sALFF correlated with the spatial distribution of serotonin transporter, dopamine, glutamate systems, and GABAergic, and the alterations of dALFF correlated with the spatial distribution of serotonin transporter, dopaminergic, and the vesicular acetylcholine transporter (VAChT).
CONCLUSIONS: Chronic tinnitus exhibits not only abnormalities in sALFF, but also aberrant dynamic temporal fluctuations, which spatially correlate with the distribution patterns of different neurotransmitter systems, thereby deepening the understanding of the neural mechanisms underlying chronic tinnitus.