血清25-羟基维生素D水平与双侧前庭病之间的关联：一项病例对照研究。
Association between serum 25-hydroxyvitamin D levels and bilateral vestibulopathy: A case-control study.
文献信息
| PMID | 42715906 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Dongxiao Zhou |
| 作者单位 | Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, China. |
| 期刊 | Clinics (Sao Paulo, Brazil) |
| SCI 分区 | Q2 |
| IF | 2.4 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
背景： 双侧前庭病（BVP）的病因复杂。鉴于维生素D与多种前庭疾病（包括良性阵发性位置性眩晕和前庭神经炎）之间的密切关联，本研究旨在探讨血清维生素D水平与BVP之间的关系。
方法： 这项单中心回顾性病例对照研究纳入了35例BVP患者和70例年龄、性别匹配的健康对照者（HC）。收集了人口学信息、临床数据（包括25-羟基维生素D（25(OH)D）水平）以及前庭评估结果。
结果： BVP组的血清25(OH)D水平显著低于HC组（18.58±5.80 vs. 24.25±5.91 ng/mL，p < 0.001）。BVP组中97.14%的患者存在维生素D不足或缺乏（缺乏，60.00%；不足，37.14%）。在BVP患者中，未发现维生素D不足或缺乏与病程、就诊季节、居住纬度或基础疾病之间存在显著关联。二元logistic回归分析显示，血清25(OH)D水平与BVP相关，比值比为0.846（95% CI 0.765-0.935；p = 0.001）。
结论： BVP患者的血清25(OH)D水平显著低于HC，提示维生素D不足/缺乏与BVP之间存在关联。
英文摘要
BACKGROUND: The etiology of Bilateral Vestibulopathy (BVP) is complex. Given the close association between vitamin D and various vestibular disorders, including benign paroxysmal positional vertigo and vestibular neuritis, this study aims to investigate the relationship between serum vitamin D levels and BVP.
METHODS: This single-center retrospective case-control study included 35 patients with BVP and 70 age- and sex-matched healthy controls (HC). Demographic information, clinical data, including 25-Hydroxyvitamin D (25(OH)D) levels, and vestibular assessment results were collected.
RESULTS: Serum 25(OH)D levels were significantly lower in the BVP group than in the HC group (18.58±5.80 vs. 24.25±5.91 ng/mL, p < 0.001). Insufficient or deficient vitamin D levels were observed in 97.14% of patients in the BVP group (deficiency, 60.00%; insufficiency, 37.14%). No significant association was found between vitamin D insufficiency or deficiency and the disease duration, season of visit, residential latitude, or underlying medical conditions in patients with BVP. Binary logistic regression analysis showed that serum 25(OH)D levels were associated with BVP, with an odds ratio of 0.846 (95% CI 0.765-0.935; p = 0.001).
CONCLUSION: Serum 25(OH)D levels were significantly lower in patients with BVP than in HC, suggesting an association between vitamin D insufficiency/deficiency and BVP.