使用反流症状指数量化中国LPR筛查阴性患者在SARS-CoV-2感染前及感染期间咽喉症状负担：一项前瞻性随访研究
Using the reflux symptom index to quantify throat symptom burden in LPR-screened-negative patients before and during SARS-CoV-2 infection in China: a prospective follow-up study.
文献信息
| PMID | 42712454 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Ying Wang |
| 作者单位 | Department of Otolaryngology Head and Neck Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, China. |
| 期刊 | Frontiers in medicine |
| SCI 分区 | Q1 |
| IF | 3.7 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
目的： 本研究旨在使用反流症状指数（RSI）量化在Omicron优势流行期LPR筛查阴性患者于SARS-CoV-2感染前及感染期间的咽喉症状负担，并识别感染期间与RSI评分升高独立相关的因素。
方法： 这项前瞻性随访研究纳入了428名在中国Omicron优势流行期（2022年12月至2023年3月）感染SARS-CoV-2的LPR筛查阴性参与者。RSI问卷在两个时间点进行：感染前基线和随访时。第二份问卷在感染发病后≥4周完成，参与者回顾性回忆发病前2周内经历的急性症状。采用配对样本t检验、McNemar检验和多变量线性回归进行分析。
结果： 平均年龄为37.59 ± 11.56岁；64.7%为女性。平均RSI总分从基线的5.04 ± 5.98显著升高至感染期间的9.68 ± 7.48（平均ΔRSI = +4.64；p < 0.001）。RSI > 13的比例从9.1%上升至25.9%（p < 0.001）。感染期间最常见的症状是烦人的咳嗽（79.2%）、清嗓（76.9%）和咽喉黏液过多（72.4%）。多变量线性回归确定了三个与RSI升高幅度更大独立相关的因素：鼻塞/流涕（β = 3.30，95% CI 1.99-4.60，p < 0.001）、疲劳（β = 2.53，95% CI 0.83-4.23，p = 0.004）和肌肉疼痛（β = 1.96，95% CI 0.59-3.32，p = 0.005）。
结论： 在Omicron优势流行期，SARS-CoV-2感染显著加重了LPR筛查阴性患者的咽喉症状。同时出现疲劳、鼻塞和肌肉疼痛的患者RSI升高幅度更高，可能需要更密切的临床关注。
英文摘要
OBJECTIVES: This study aimed to quantify throat symptom burden using the Reflux Symptom Index (RSI) in laryngopharyngeal reflux (LPR)-screened-negative patients before and during SARS-CoV-2 infection in the Omicron-dominant period, and to identify factors independently associated with RSI score increase during infection.
METHODS: This prospective follow-up study enrolled 428 LPR-screened-negative participants with SARS-CoV-2 infection during the Omicron-dominant period (December 2022-March 2023) in China. RSI questionnaires were administered at two time points: pre-infection baseline and follow-up. The second questionnaire was completed ≥4 weeks after infection onset, and participants retrospectively recalled acute symptoms experienced during the first 2 weeks of illness. Paired-samples t-tests, McNemar's test, and multivariable linear regression were used for analysis.
RESULTS: Mean age was 37.59 ± 11.56 years; 64.7% were female. Mean total RSI score increased significantly from 5.04 ± 5.98 at baseline to 9.68 ± 7.48 during infection (mean ΔRSI = +4.64; p < 0.001). The proportion with RSI > 13 rose from 9.1 to 25.9% (p < 0.001). The most common symptoms during infection were troublesome cough (79.2%), throat clearing (76.9%), and excess throat mucus (72.4%). Multivariable linear regression identified three factors independently associated with greater RSI increase: stuffy/runny nose (β = 3.30, 95% CI 1.99-4.60, p < 0.001), fatigue (β = 2.53, 95% CI 0.83-4.23, p = 0.004), and muscle pains (β = 1.96, 95% CI 0.59-3.32, p = 0.005).
CONCLUSION: SARS-CoV-2 infection during the Omicron-dominant period significantly worsened throat symptoms in LPR-screened-negative patients. Patients presenting with concurrent fatigue, nasal congestion, and muscle pain showed higher RSI increases and may warrant closer clinical attention.