Article record

1600匹马中鼻窦疾病的诊断病因及其与临床症状、计算机断层扫描表现和病例结局的关联。

Diagnosed causes of sinonasal disease in 1600 horses and associations with clinical signs, computed tomographic findings and case outcome.

临床研究鼻科IF 2.5Q1

文献信息

PMID	42708900
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Padraic Dixon 查看其他 22 位作者 Tim Barnett；Eric Parente；Rhiannon Morgan；John Mark O'Leary；Lieven Vlaminck；Alison Talbot；Alexandra Gillen；Tom McGinley；Moses Brennan；Henry Tremaine；Elke Polaris；Erica Dobbs；Ben Anghileri；Linda Wright；Elin Olsson；Jonathan Olijnyk；Charles Alexandre；Neil Townsend；Adam Northwood；Tim Mair；Jane Haden；Richard J M Reardon
作者单位	Independent Veterinary Consultant, Edinburgh, UK. 查看其他 21 条单位信息 Rossdales Equine Hospital, Newmarket, UK.；University of Pennsylvania, New Bolton Center, Kennett Square, Pennsylvania, USA.；IVC/Evidensia, Keynsham, Bristol, UK.；University College Dublin, Dublin, Ireland.；University of Ghent, Ghent, Belgium.；University of Liverpool Equine Hospital, Neston, UK.；Liphook Equine Hospital, Hampshire, UK.；Rainbow Equine Hospital, Malton, Yorkshire, UK.；B&W Equine Hospital, Gloucestershire, UK.；Morette Clinic, Asse, Belgium.；Rood and Riddle Equine Hospital, Lexington, Kentucky, USA.；Oakham Veterinary Hospital, Leicestershire, UK.；IVC Evidensia, Helsingborg, Sweden.；IVC Evidensia, Strömsholm, Sweden.；Swedish University of Agricultural Sciences, Uppsala, Sweden.；University of Liege, Liège, Belgium.；Three Counties Equine Hospital, Worcestershire, UK.；Royal Veterinary College, London, UK.；Bell Equine Veterinary Clinic, Maidstone, Kent, UK.；Equine Dental Clinic, Wimborne, UK.；University of Edinburgh, Edinburgh, UK.
期刊	Equine veterinary journal
SCI 分区	Q1
IF	2.5
研究类型	临床研究 · 临床
所属专科	鼻科

中文摘要

背景： 使用计算机断层扫描（CT）成像极大地提高了马鼻窦疾病的诊断水平。
目的： 探讨马鼻窦疾病中特定诊断与临床及CT表现之间的关联，以及特定诊断与病例结局之间的关联。
研究设计： 回顾性病例系列。
方法： 从19家马医院收集鼻窦疾病病例的医疗记录，所有病例均接受了CT成像。病例结局通过临床记录和/或联系客户及转诊兽医获得。使用逻辑回归分析检验特定诊断与临床及CT变量之间的关联，并检验特定诊断与病例结局之间的关联。
结果： 由根尖感染引起的牙源性鼻窦炎是鼻窦炎最常见的原因（n=693；占病例的43.3%）。其他原因包括原发性鼻窦炎（n=329；20.6%）、鼻窦囊肿（n=178；11.1%）、进行性筛窦血肿（PEH）（n=100；6.3%）、创伤性鼻窦疾病（n=90；5.6%）、鼻窦肿瘤或疑似肿瘤（n=86；5.4%）、其他非肿瘤性鼻窦生长物（n=11；0.6%）、真菌感染（n=65；4.1%）、鼻窦气囊肿（n=5；0.3%）、口鼻瘘相关鼻窦炎（n=4；0.25%）、鼻窦黏液囊肿（n=2；0.13%）和面部缝线感染（n=1；0.06%）病例。面部肿胀在鼻窦囊肿、肿瘤、创伤和真菌感染中比其他诊断更常见。鼻恶臭在牙源性鼻窦炎中最常见。鼻气流阻塞在鼻窦囊肿、PEH和肿瘤中最常见。鼻甲泡积脓在鼻窦囊肿、PEH、创伤和肿瘤（较少化脓性类型的鼻窦炎）中最不常见。更严重程度的骨质增生与鼻窦囊肿和肿瘤相关。鼻窦肿瘤（比值比[OR] 0.03，95%置信区间[CI] 0.01-0.07）和PEH（OR 0.23，95% CI 0.12-0.43）治愈的可能性显著低于原发性鼻窦炎。
主要局限性： 这是一项回顾性研究，部分病例未进行组织学检查。
结论： 马鼻窦疾病有多种潜在病因，影响临床表现和结局。

英文摘要

BACKGROUND: The diagnosis of equine sinonasal disorders has been greatly enhanced by using computed tomographic (CT) imaging.
OBJECTIVES: To explore associations between specific diagnoses and clinical and CT findings and between specific diagnoses and case outcome in equine sinonasal disease.
STUDY DESIGN: Retrospective case series.
METHODS: Data were collected from medical records from 19 equine hospitals on cases of sinonasal disease, all of which underwent CT imaging. Case outcome was obtained from clinical records, and/or by contacting clients and referring veterinarians. Logistic regression analysis was used to examine associations between specific diagnoses and clinical and CT variables and examine associations between specific diagnoses and case outcome.
RESULTS: Dental sinusitis due to apical infection was the most common cause of sinusitis (n = 693; 43.3% of cases). Other causes were primary sinusitis (n = 329; 20.6%), sinus cyst (n = 178; 11.1%), progressive ethmoid haematoma (PEH) (n = 100; 6.3%), traumatic sinonasal disease (n = 90; 5.6%), sinonasal neoplasia or suspect neoplasia (n = 86; 5.4%), other non-neoplastic sinonasal growths (n = 11; 0.6%), mycotic infection (n = 65; 4.1%), sinus pneumocele (n = 5; 0.3%), oro-nasal fistulae-related sinusitis (n = 4; 0.25%), sinus mucocele (n = 2; 0.13%) and facial suture infection (n = 1; 0.06%) cases. Facial swelling was more common with sinonasal cysts, tumours, trauma and mycosis than other diagnoses. Nasal malodour was most common with dental sinusitis. Nasal airflow obstruction was most common with sinonasal cysts, PEH and tumours. Empyema of the nasal conchal bullae was least common with sinus cysts, PEH, trauma and tumours (less purulent types of sinusitis). More severe grades of hyperostosis were associated with sinus cysts and tumours. Sinonasal tumours (odds ratio [OR] 0.03, 95% confidence interval [CI] 0.01-0.07) and PEH (OR 0.23, 95% CI 0.12-0.43) had a significantly lower likelihood of cure than primary sinusitis.
MAIN LIMITATIONS: This was a retrospective study, and histology was not performed in some cases.
CONCLUSIONS: Equine sinonasal disease has a range of underlying causes which impacts the clinical presentation and outcome.