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前庭时间常数与真实驾驶中个体晕动病易感性

Vestibular time constant and individual susceptibility to motion sickness in real-world driving.

临床研究耳科IF 4.8Q1

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中文摘要

晕动病是自动驾驶汽车接受度面临的一个重要挑战。尽管晕动病易感性问卷(MSSQ)被广泛使用,但它依赖于回顾性自我报告,并不能直接捕捉前庭特征。本研究考察了前庭时间常数(VTC)——反映速度存储机制——与道路驾驶中晕动病严重程度之间的关联。在24名女性成年人中测量了VTC;21人完成了四次30分钟加速试验,所有24人完成了九次30分钟减速试验,涉及再生制动。使用痛苦量表(MISC)反复评估晕动病严重程度。MSSQ评分与MISC衍生的结果显示出微弱、无显著性的关联,而较长的VTC与更严重的症状相关,尤其是在减速条件下以及出现症状的参与者中。参与者水平的受试者工作特征分析显示,VTC在区分达到恶心阈值(MISC ≥ 6)的参与者方面优于MSSQ。在减速条件下,这一差异具有显著性(曲线下面积,0.89对0.60;DeLong p = 0.048)。VTC的关联在减速条件下描述性地更强,可能反映了制动相关前庭刺激的条件特异性特征。这些发现表明,VTC提供了客观的生理信息,可能补充汽车环境中基于问卷的易感性评估。

英文摘要

Motion sickness is an important challenge for the acceptance of autonomous vehicles. Although the Motion Sickness Susceptibility Questionnaire (MSSQ) is widely used, it relies on retrospective self-report and does not directly capture vestibular characteristics. This study examined the association between the vestibular time constant (VTC), which reflects the velocity storage mechanism, and motion sickness severity during on-road driving. VTC was measured in 24 female adults; 21 completed four 30-min acceleration sessions, and all 24 completed nine 30-min deceleration sessions involving regenerative braking. Motion sickness severity was repeatedly assessed using the Misery Scale (MISC). MSSQ scores showed weak, non-significant associations with MISC-derived outcomes, whereas longer VTCs were associated with greater symptom severity, particularly under deceleration and among participants who developed symptoms. Participant-level receiver operating characteristic analyses showed that the VTC discriminated participants who reached the nausea threshold (MISC ≥ 6) better than the MSSQ. Under deceleration, this difference was significant (area under the curve, 0.89 versus 0.60; DeLong p = 0.048). VTC associations were descriptively stronger under deceleration, possibly reflecting condition-specific characteristics of braking-related vestibular stimulation. These findings indicate that the VTC provides objective physiological information that may complement questionnaire-based susceptibility assessment in automotive environments.